3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria.
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Effects of Zidovudine Treatment on Heart mRNA Expression and Mitochondrial DNA Copy Number Associated with Alterations in Deoxynucleoside Triphosphate Composition in a Neonatal Rat ModelThe kinetic effects on thymidine kinase 2 by enzyme-bound dTTP may explain the mitochondrial side effects of antiviral thymidine analogsClicking 3'-azidothymidine into novel potent inhibitors of human immunodeficiency virus.Mutational analysis of the mitochondrial tRNA genes and flanking regions in umbilical cord tissue from uninfected infants receiving AZT-based therapies for prophylaxis of HIV-1.A review comparing deoxyribonucleoside triphosphate (dNTP) concentrations in the mitochondrial and cytoplasmic compartments of normal and transformed cellsZidovudine inhibits thymidine phosphorylation in the isolated perfused rat heart.Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance: transgenic TK2, mtDNA, and antiretrovirals.Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondriaPyrimidine nucleoside depletion sensitizes to the mitochondrial hepatotoxicity of the reverse transcriptase inhibitor stavudine.Effect of AZT on thymidine phosphorylation in cultured H9c2, U-937, and Raji cell lines.Effects of zidovudine and stavudine on mitochondrial DNA of differentiating 3T3-F442a cells are not associated with imbalanced deoxynucleotide pools.Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction.Central role of mitochondria in drug-induced liver injury.Nonpolar nucleoside mimics as active substrates for human thymidine kinases.Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: implications for 3'-azido-3'-deoxythymidine-dependent cardiotoxicity.Addressing the selectivity and toxicity of antiviral nucleosides.
P2860
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P2860
3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria.
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
3'-Azido-3'-deoxythymidine (AZ ...... heart and liver mitochondria.
@ast
3'-Azido-3'-deoxythymidine (AZ ...... heart and liver mitochondria.
@en
3'-Azido-3'-deoxythymidine
@nl
type
label
3'-Azido-3'-deoxythymidine (AZ ...... heart and liver mitochondria.
@ast
3'-Azido-3'-deoxythymidine (AZ ...... heart and liver mitochondria.
@en
3'-Azido-3'-deoxythymidine
@nl
prefLabel
3'-Azido-3'-deoxythymidine (AZ ...... heart and liver mitochondria.
@ast
3'-Azido-3'-deoxythymidine (AZ ...... heart and liver mitochondria.
@en
3'-Azido-3'-deoxythymidine
@nl
P2860
P1476
3'-Azido-3'-deoxythymidine (AZ ...... heart and liver mitochondria.
@en
P2093
Edward E McKee
Matthew D Lynx
P2860
P304
P356
10.1016/J.BCP.2006.04.004
P407
P577
2006-04-25T00:00:00Z