Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism.
about
Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system.Nicotine metabolism in African Americans and European Americans: variation in glucuronidation by ethnicity and UGT2B10 haplotype.Characterization of raloxifene glucuronidation: potential role of UGT1A8 genotype on raloxifene metabolism in vivo.Predictors of smoking reduction among Blacks.UGT2B10 genotype influences nicotine glucuronidation, oxidation, and consumption.Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphismsNicotine N-glucuronidation relative to N-oxidation and C-oxidation and UGT2B10 genotype in five ethnic/racial groups.Biomarkers of Exposure to New and Emerging Tobacco and Nicotine Delivery Products.Characterization of 17-dihydroexemestane glucuronidation: potential role of the UGT2B17 deletion in exemestane pharmacogenetics.Variation in trans-3'-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake.The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populationsUGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers.The Role of Genetics in Nicotine Dependence: Mapping the Pathways from Genome to Syndrome.Genetic influences on individual differences in nicotine glucuronidationGlucuronidation of trans-3'-hydroxycotinine by UGT2B17 and UGT2B10.Effects of menthol on tobacco smoke exposure, nicotine dependence, and NNAL glucuronidation.Glucuronidation of tobacco-specific nitrosamines by UGT2B10Regulation of UGT2B Expression and Activity by miR-216b-5p in Liver Cancer Cell Lines.Prediction of deleterious non-synonymous single-nucleotide polymorphisms of human uridine diphosphate glucuronosyltransferase genes.Association between Glucuronidation Genotypes and Urinary NNAL Metabolic Phenotypes in Smokers.Exposure to the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers from 3 populations with different risks of lung cancer.The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among European AmericansRegulation of UDP-glucuronosyltransferase 1A1 expression and activity by microRNA 491-3p.N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases.Transcriptional regulation of human UDP-glucuronosyltransferase genes.To quit or not: Vulnerability of women to smoking tobacco.Human UDP-Glucuronosyltransferase (UGT) 2B10: Validation of Cotinine as a Selective Probe Substrate, Inhibition by UGT Enzyme-Selective Inhibitors and Antidepressant and Antipsychotic Drugs, and Structural Determinants of Enzyme Inhibition.The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro-in vivo extrapolation of drug clearance and drug-drug interaction potentiaEffect of UGT2B10, UGT2B17, FMO3, and OCT2 genetic variation on nicotine and cotinine pharmacokinetics and smoking in African Americans.Low Cotinine Glucuronidation Results in Higher Serum and Saliva Cotinine in African American Compared to White Smokers.Longitudinal Influence of Pregnancy on Nicotine Metabolic Pathways.Influence of UGT2B10 genotype on urinary excretion of NNAL-N-glucuronide by African American smokers.Posttranscriptional regulation of UGT2B10 hepatic expression and activity by alternative splicing.
P2860
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P2860
Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism.
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Glucuronidation of nicotine an ...... don 67 (Asp>Tyr) polymorphism.
@ast
Glucuronidation of nicotine an ...... don 67 (Asp>Tyr) polymorphism.
@en
Glucuronidation of nicotine an ...... nction by the UGT2B10 Codon 67
@nl
type
label
Glucuronidation of nicotine an ...... don 67 (Asp>Tyr) polymorphism.
@ast
Glucuronidation of nicotine an ...... don 67 (Asp>Tyr) polymorphism.
@en
Glucuronidation of nicotine an ...... nction by the UGT2B10 Codon 67
@nl
prefLabel
Glucuronidation of nicotine an ...... don 67 (Asp>Tyr) polymorphism.
@ast
Glucuronidation of nicotine an ...... don 67 (Asp>Tyr) polymorphism.
@en
Glucuronidation of nicotine an ...... nction by the UGT2B10 Codon 67
@nl
P2093
P1433
P1476
Glucuronidation of nicotine an ...... don 67 (Asp>Tyr) polymorphism.
@en
P2093
Andrea S Blevins-Primeau
Joshua E Muscat
Philip Lazarus
Ryan W Dellinger
P304
P356
10.1158/0008-5472.CAN-07-2245
P407
P577
2007-10-01T00:00:00Z