Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51.
about
Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast.CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM).4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection.
P2860
Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51.
description
2014 nî lūn-bûn
@nan
2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Binding mode and potency of N- ...... eting Trypanosoma cruzi CYP51.
@ast
Binding mode and potency of N- ...... eting Trypanosoma cruzi CYP51.
@en
Binding mode and potency of N- ...... eting Trypanosoma cruzi CYP51.
@nl
type
label
Binding mode and potency of N- ...... eting Trypanosoma cruzi CYP51.
@ast
Binding mode and potency of N- ...... eting Trypanosoma cruzi CYP51.
@en
Binding mode and potency of N- ...... eting Trypanosoma cruzi CYP51.
@nl
prefLabel
Binding mode and potency of N- ...... eting Trypanosoma cruzi CYP51.
@ast
Binding mode and potency of N- ...... eting Trypanosoma cruzi CYP51.
@en
Binding mode and potency of N- ...... eting Trypanosoma cruzi CYP51.
@nl
P2093
P2860
P356
P1476
Binding mode and potency of N- ...... eting Trypanosoma cruzi CYP51.
@en
P2093
Claudia M Calvet
Danielle Kellar
Debora F Vieira
Jonathan B Johnston
Jun Yong Choi
Larissa M Podust
Michael D Cameron
William R Roush
P2860
P304
10162-10175
P356
10.1021/JM501568B
P407
P577
2014-11-25T00:00:00Z