Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. - Wikidata - awgldk - TriplyDB

Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.

Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.

http://www.wikidata.org/entity/Q34701731

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Strategies to achieve conditional gene mutation in mice Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching Mechanisms for insulin resistance: common threads and missing links Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms RNA expression analysis of passive transfer myasthenia supports extraocular muscle as a unique immunological environment.PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle.Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling Muscle-specific deletion of comparative gene identification-58 (CGI-58) causes muscle steatosis but improves insulin sensitivity in male mice.Re-patterning of skeletal muscle energy metabolism by fat storage-inducing transmembrane protein 2.(R)-α-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria.Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.A murine model of isolated cardiac steatosis leads to cardiomyopathy.Skeletal intramyocellular lipid metabolism and insulin resistance.Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications Citrus flavonoid, naringenin, increases locomotor activity and reduces diacylglycerol accumulation in skeletal muscle of obese ovariectomized mice.Relationships between circadian rhythms and modulation of gene expression by glucocorticoids in skeletal muscle Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance.Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity.The Randle cycle revisited: a new head for an old hat.Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77.Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling.Shedding light on the enigma of myocardial lipotoxicity: the involvement of known and putative regulators of fatty acid storage and mobilization.Revisiting the diacylglycerol-induced insulin resistance hypothesis.Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia.Therapeutic strategies for metabolic diseases: Small-molecule diacylglycerol acyltransferase (DGAT) inhibitors.Diacylglycerol acyltransferase-2 (DGAT2) and monoacylglycerol acyltransferase-2 (MGAT2) interact to promote triacylglycerol synthesis Regulation of diacylglycerol acyltransferase 2 protein stability by gp78-associated endoplasmic-reticulum-associated degradation.DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation.Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides and de novo synthesized fatty acids in HepG2 cells.Chronic high fat feeding attenuates load-induced hypertrophy in mice.Vascular gene expression in mice overexpressing human endothelin-1 targeted to the endothelium.Accumulation of ceramide in slow-twitch muscle contributes to the development of insulin resistance in the obese JCR:LA-cp rat.Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock

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P2860

Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.

http://www.wikidata.org/entity/Q34701731

description

2007 nî lūn-bûn

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2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2007 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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AJPENDO.00158.2007

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American Journal of Physiology - Endocrinology and Metabolism

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Increased lipid accumulation a ...... n glycolytic (type II) muscle.

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Christopher B Newgard

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Malin C Levin

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Mara Monetti

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Matthew J Watt

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Mini P Sajan

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Robert D Stevens

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Robert V Farese

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scholarly article

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10.1152/AJPENDO.00158.2007

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6

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293

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2007-10-16T00:00:00Z

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5905740

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