Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer
about
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomasDNA polymerase ε and its roles in genome stabilityDo mutator mutations fuel tumorigenesis?Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replicationAvalanching mutations in biallelic mismatch repair deficiency syndromeCombined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancersA panoply of errors: polymerase proofreading domain mutations in cancerDNA polymerase ε and δ exonuclease domain mutations in endometrial cancerWhole-exome sequencing characterizes the landscape of somatic mutations and copy number alterations in adrenocortical carcinoma.Normally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variantEukaryotic Mismatch Repair in Relation to DNA ReplicationProcessing ribonucleotides incorporated during eukaryotic DNA replication.A mutation in POLE predisposing to a multi-tumour phenotype.Mutations in POLE and survival of colorectal cancer patients--link to disease stage and treatment.Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancerDNA damage and breast cancerDevelopment of cancer-initiating cells and immortalized cells with genomic instability.Characterization of the mutational landscape of anaplastic thyroid cancer via whole-exome sequencing.Differences in genome-wide repeat sequence instability conferred by proofreading and mismatch repair defects.Volatility of Mutator Phenotypes at Single Cell ResolutiondNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.Quantifying the contributions of base selectivity, proofreading and mismatch repair to nuclear DNA replication in Saccharomyces cerevisiae.Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis.Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma.Important molecular genetic markers of colorectal cancer.Mechanisms of base substitution mutagenesis in cancer genomes.Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase δ mutation in human cells.Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.Family A and B DNA Polymerases in Cancer: Opportunities for Therapeutic Interventions.DNA Polymerase ɛ Deficiency Leading to an Ultramutator Phenotype: A Novel Clinically Relevant Entity.Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome.Frequency and phenotypic spectrum of germline mutations in POLE and seven other polymerase genes in 266 patients with colorectal adenomas and carcinomas.Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae.Risk of colorectal cancer for carriers of a germ-line mutation in POLE or POLD1.
P2860
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P2860
Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Concurrent genetic alterations ...... air in human colorectal cancer
@ast
Concurrent genetic alterations ...... air in human colorectal cancer
@en
Concurrent genetic alterations ...... air in human colorectal cancer
@nl
type
label
Concurrent genetic alterations ...... air in human colorectal cancer
@ast
Concurrent genetic alterations ...... air in human colorectal cancer
@en
Concurrent genetic alterations ...... air in human colorectal cancer
@nl
prefLabel
Concurrent genetic alterations ...... air in human colorectal cancer
@ast
Concurrent genetic alterations ...... air in human colorectal cancer
@en
Concurrent genetic alterations ...... air in human colorectal cancer
@nl
P2093
P2860
P356
P1476
Concurrent genetic alterations ...... air in human colorectal cancer
@en
P2093
Akinori Egashira
Akiyoshi Shimamoto
Kaname Miyashita
Mayuko Inoue
Rintaro Yoshida
Shinya Oda
Yoshishiro Kakeji
P2860
P2888
P304
P356
10.1038/EJHG.2010.216
P577
2010-12-15T00:00:00Z