Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice - Wikidata - awgldk - TriplyDB

Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice

Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice

http://www.wikidata.org/entity/Q34713732

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In a mouse model relevant for post-traumatic stress disorder, selective brain steroidogenic stimulants (SBSS) improve behavioral deficits by normalizing allopregnanolone biosynthesis.SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake Isolation associated aggression--a consequence of recovery from defeat in a territorial animal Distinct Types of Feeding Related Neurons in Mouse Hypothalamus.The Sturm und Drang of anabolic steroid use: angst, anxiety, and aggression The BTBR T+ tf/J mouse model for autism spectrum disorders-in search of biomarkers.Growth arrest and DNA-damage-inducible, beta (GADD45b)-mediated DNA demethylation in major psychosis Mad men, women and steroid cocktails: a review of the impact of sex and other factors on anabolic androgenic steroids effects on affective behaviors Targeting neurosteroid synthesis as a therapy for schizophrenia-related alterations induced by early psychosocial stress Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder Post-weaning social isolation impairs observational fear conditioning Neurosteroids reduce social isolation-induced behavioral deficits: a proposed link with neurosteroid-mediated upregulation of BDNF expression.Enhanced fear responses in mice treated with anabolic androgenic steroids.Effects of bisphenol-A and other endocrine disruptors compared with abnormalities of schizophrenia: an endocrine-disruption theory of schizophrenia.Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder.Biosynthesis and biological action of pineal allopregnanolone.Estrogen is necessary for 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats.TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model.Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice.Female mice with deletion of Type One 5α-reductase have reduced reproductive responding during proestrus and after hormone-priming Involvement of pregnane xenobiotic receptor in mating-induced allopregnanolone formation in the midbrain and hippocampus and brain-derived neurotrophic factor in the hippocampus among female rats.Neurosteroid, GABAergic and hypothalamic pituitary adrenal (HPA) axis regulation: what is the current state of knowledge in humans?Regional distribution of 5α-reductase type 2 in the adult rat brain: an immunohistochemical analysis Neurosteroid biosynthesis downregulation and changes in GABAA receptor subunit composition: A biomarker axis in stress-induced cognitive and emotional impairment.S-norfluoxetine microinfused into the basolateral amygdala increases allopregnanolone levels and reduces aggression in socially isolated mice.Reduction of circulating and selective limbic brain levels of (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP) following forced swim stress in C57BL/6J mice Localization of brain 5α-reductase messenger RNA in mice selectively bred for high chronic alcohol withdrawal severity.Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder Biosynthesis, mode of action, and functional significance of neurosteroids in the purkinje cell.The neurosteroid allopregnanolone modulates specific functions in central and peripheral glial cells.Type 1 5α-reductase may be required for estrous cycle changes in affective behaviors of female mice Why may allopregnanolone help alleviate loneliness?Neurosteroids, stress and depression: potential therapeutic opportunities.Social Isolation During Postweaning Development Causes Hypoactivity of Neurons in the Medial Nucleus of the Male Rat Amygdala.Isolation Rearing Reduces Neuronal Excitability in Dentate Gyrus Granule Cells of Adolescent C57BL/6J Mice: Role of GABAergic Tonic Currents and Neurosteroids Progesterone facilitates exploration, affective and social behaviors among wildtype, but not 5α-reductase Type 1 mutant, mice.Targeting neurosteroidogenesis as therapy for PTSD.Cortisol metabolic predictors of response to psychotherapy for symptoms of PTSD in survivors of the World Trade Center attacks on September 11, 2001.Toward a neurology of loneliness.DNA methyltransferases1 (DNMT1) and 3a (DNMT3a) colocalize with GAD67-positive neurons in the GAD67-GFP mouse brain.

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Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice

http://www.wikidata.org/entity/Q34713732

description

2007 nî lūn-bûn

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2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2007 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2007年の論文

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Down-regulation of neurosteroi ...... ation-induced behavior in mice

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Down-regulation of neurosteroi ...... ation-induced behavior in mice

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Down-regulation of neurosteroi ...... ation-induced behavior in mice

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Down-regulation of neurosteroi ...... ation-induced behavior in mice

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Down-regulation of neurosteroi ...... ation-induced behavior in mice

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Down-regulation of neurosteroi ...... ation-induced behavior in mice

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Down-regulation of neurosteroi ...... ation-induced behavior in mice

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Down-regulation of neurosteroi ...... ation-induced behavior in mice

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Down-regulation of neurosteroi ...... ation-induced behavior in mice

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Proceedings of the National Academy of Sciences of the United States of America

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Down-regulation of neurosteroi ...... ation-induced behavior in mice

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Alessandro Guidotti

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Bashkim Kadriu

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Erminio Costa

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Fabio Pibiri

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Graziano Pinna

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Roberto C Agís-Balboa

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P2860

Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation

Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis

GABAergic cells are the major postsynaptic targets of mossy fibers in the rat hippocampus

Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake

Interneurons of the hippocampus

Neurosteroid modulation of synaptic and extrasynaptic GABAA receptors

Encoding, consolidation, and retrieval of contextual memory: differential involvement of dorsal CA3 and CA1 hippocampal subregions.

Two-dimensional versus three-dimensional cell counting: a practical perspective.

Neurosteroids act on recombinant human GABAA receptors.

The amygdaloid complex: anatomy and physiology.

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104

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18003893

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2141846

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