The natural human IgM antibody PAT-SM6 induces apoptosis in primary human multiple myeloma cells by targeting heat shock protein GRP78. - Wikidata - awgldk - TriplyDB

The natural human IgM antibody PAT-SM6 induces apoptosis in primary human multiple myeloma cells by targeting heat shock protein GRP78.

The natural human IgM antibody PAT-SM6 induces apoptosis in primary human multiple myeloma cells by targeting heat shock protein GRP78.

http://www.wikidata.org/entity/Q34718149

about

Melanoma and the Unfolded Protein Response Drugging the unfolded protein response in acute leukemias Development of Novel Immunotherapies for Multiple Myeloma GRP78-directed immunotherapy in relapsed or refractory multiple myeloma - results from a phase 1 trial with the monoclonal immunoglobulin M antibody PAT-SM6.Characterization and mechanism of stress-induced translocation of 78-kilodalton glucose-regulated protein (GRP78) to the cell surface.Selection and identification of ligand peptides targeting a model of castrate-resistant osteogenic prostate cancer and their receptors.Evasion and interactions of the humoral innate immune response in pathogen invasion, autoimmune disease, and cancer Role of GRP78 in promoting therapeutic-resistant breast cancer Immunoglubolin dynamics and cancer prevalence in Tasmanian devils (Sarcophilus harrisii).Activated α2-Macroglobulin Regulates Transcriptional Activation of c-MYC Target Genes through Cell Surface GRP78 Protein.Tumor-Specific Binding of Radiolabeled PEGylated GIRLRG Peptide: A Novel Agent for Targeting Cancers.In vivo amelioration of endogenous antitumor autoantibodies via low-dose P4N through the LTA4H/activin A/BAFF pathway.Smac mimetic LCL161 overcomes protective ER stress induced by obatoclax, synergistically causing cell death in multiple myeloma.Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction.Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential Intracellular antigens as targets for antibody based immunotherapy of malignant diseases.Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM Expression and release of glucose-regulated protein-78 (GRP78) in multiple myeloma.Monoclonal Antibody Therapies for Hematological Malignancies: Not Just Lineage-Specific Targets.Site-Specific N-Glycosylation of Recombinant Pentameric and Hexameric Human IgM.

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The natural human IgM antibody PAT-SM6 induces apoptosis in primary human multiple myeloma cells by targeting heat shock protein GRP78.

http://www.wikidata.org/entity/Q34718149

description

2013 nî lūn-bûn

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2013 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2013 թվականի մայիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

The natural human IgM antibody ...... ting heat shock protein GRP78.

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The natural human IgM antibody ...... ting heat shock protein GRP78.

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The natural human IgM antibody ...... ting heat shock protein GRP78.

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type

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The natural human IgM antibody ...... ting heat shock protein GRP78.

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The natural human IgM antibody ...... ting heat shock protein GRP78.

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The natural human IgM antibody ...... ting heat shock protein GRP78.

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The natural human IgM antibody ...... ting heat shock protein GRP78.

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The natural human IgM antibody ...... ting heat shock protein GRP78.

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Andreas Rosenwald

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Charlotte Morgner

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Frank Hensel

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Johannes Duell

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Leo Rasche

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Manik Chatterjee

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Max S Topp

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Stephanie Brändlein

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P2860

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High throughput screening for antibody induced complement-dependent cytotoxicity in early antibody discovery using homogeneous macroconfocal fluorescence imaging.

Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP.

Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity

Randomized, placebo-controlled trial of HA-1A, a human monoclonal antibody to endotoxin, in children with meningococcal septic shock. European Pediatric Meningococcal Septic Shock Trial Study Group.

Preclinical anti-myeloma activity of the novel HDAC-inhibitor JNJ-26481585.

Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors.

The glucose-regulated proteins: stress induction and clinical applications.

Human monoclonal antibodies to sialyl-Lewis (CA19.9) with potent CDC, ADCC, and antitumor activity

Therapeutic monoclonal antibodies for multiple myeloma: an update and future perspectives.

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Hermann Einsele

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2013-05-07T00:00:00Z

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236693379

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