FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons. - Wikidata - awgldk - TriplyDB

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

http://www.wikidata.org/entity/Q34718530

about

Fingolimod for multiple sclerosis and emerging indications: appropriate patient selection, safety precautions, and special considerations Fingolimod for the treatment of neurological diseases-state of play and future perspectives Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal Neurons Neurodegeneration in Autoimmune Optic Neuritis Is Associated with Altered APP Cleavage in Neurons and Up-Regulation of p53 Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer's disease.Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis.Sphingomimetic multiple sclerosis drug FTY720 activates vesicular synaptobrevin and augments neuroendocrine secretion.Altered Sphingolipid Balance in Capillary Cerebral Amyloid Angiopathy.Nuclear Lipids in the Nervous System: What they do in Health and Disease.Crosstalk between sphingolipids and vitamin D3: potential role in the nervous system.Fingolimod induces neuronal-specific gene expression with potential neuroprotective outcomes in maturing neuronal progenitor cells exposed to HIV.Implication of sphingosine-1-phosphate signaling in diseases: molecular mechanism and therapeutic strategies.FTY720 attenuates excitotoxicity and neuroinflammation.Sphingosine-1-phosphate and its effect on glucose deprivation/glucose reload stress: from gene expression to neuronal survival De novo Synthesis of Sphingolipids Is Defective in Experimental Models of Huntington's Disease.Expansion of Sphingosine Kinase and Sphingosine-1-Phosphate Receptor Function in Normal and Cancer Cells: From Membrane Restructuring to Mediation of Estrogen Signaling and Stem Cell Programming.Prominence of central sphingosine-1-phosphate receptor-1 in attenuating aβ-induced injury by fingolimod.Sphingosin-1-phosphate Receptor 1: a Potential Target to Inhibit Neuroinflammation and Restore the Sphingosin-1-phosphate Metabolism.Sphingolipid Metabolism: A New Therapeutic Opportunity for Brain Degenerative Disorders.Phospholipid and Lipid Derivatives as Potential Neuroprotective Compounds TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes

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FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

http://www.wikidata.org/entity/Q34718530

description

2013 nî lūn-bûn

@nan

2013 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2013 թվականի մայիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

@wuu

name

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

@ast

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

@en

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

@nl

type

label

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

@ast

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

@en

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

@nl

prefLabel

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

@ast

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

@en

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

@nl

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JOURNAL.PONE.0064050

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FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons

@en

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Hayato Isshiki

http://www.w3.org/2001/XMLSchema#string

Ihori Ebinuma

http://www.w3.org/2001/XMLSchema#string

Koji Takeo

http://www.w3.org/2001/XMLSchema#string

Nobumasa Takasugi

http://www.w3.org/2001/XMLSchema#string

Satoko Osawa

http://www.w3.org/2001/XMLSchema#string

Takeshi Iwatsubo

http://www.w3.org/2001/XMLSchema#string

Tomoki Sasaki

http://www.w3.org/2001/XMLSchema#string

P2860

The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor

Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth

Deregulation of sphingolipid metabolism in Alzheimer's disease.

The secretases: enzymes with therapeutic potential in Alzheimer disease.

Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis.

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation.

Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis.

"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets.

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e64050

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scholarly article

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10.1371/JOURNAL.PONE.0064050

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23667698

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