Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor.
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Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growthThe inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathwayBeta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine modelThe selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptorsMurine ventricular L-type Ca(2+) current is enhanced by zinterol via beta(1)-adrenoceptors, and is reduced in TG4 mice overexpressing the human beta(2)-adrenoceptorItraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growthTreatment with inverse agonists enhances baseline atrial contractility in transgenic mice with chronic beta2-adrenoceptor activationReal-time analysis of dopamine: antagonist interactions at recombinant human D2long receptor upon modulation of its activation stateBAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activityCharacterization of beta(1)-selectivity, adrenoceptor-G(s)-protein interaction and inverse agonism of nebivolol in human myocardiumRecruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactionsInverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptorsβ2-adrenoceptor transfection enhances contractile reserve of isolated rat ventricular myocytes exposed to chronic isoprenaline stimulation by improving β1-adrenoceptor responsivenessIncreased platelet activation and thrombosis in transgenic mice expressing constitutively active P2Y12.Naturally occurring mutations of the luteinizing-hormone receptor: lessons learned about reproductive physiology and G protein-coupled receptors.β-Adrenergic receptor subtype signaling in heart: from bench to bedside.Inverse agonism at G protein-coupled receptors: (patho)physiological relevance and implications for drug discovery.High constitutive activity of native H3 receptors regulates histamine neurons in brain.Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle.Olfactory transduction is intrinsically noisy.Induction of M2 regulatory macrophages through the β2-adrenergic receptor with protection during endotoxemia and acute lung injury.Protean agonism at histamine H3 receptors in vitro and in vivoAllosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins.Glycyrrhetic acid synergistically enhances β₂-adrenergic receptor-Gs signaling by changing the location of Gαs in lipid rafts.Quantification of receptor interactions using binding methods.Drug analysis based on signaling responses to G-protein-coupled receptors.Molecular mechanisms of anti-G-protein-coupled receptor autoantibodies.Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation.Can intellectualism stifle scientific discovery?Different intrinsic activities of bucindolol, carvedilol and metoprolol in human failing myocardium.The effect of Gi-protein inactivation on basal, and beta(1)- and beta(2)AR-stimulated contraction of myocytes from transgenic mice overexpressing the beta(2)-adrenoceptor.Cardiac-specific overexpression of human beta2 adrenoceptors in mice exposes coupling to both Gs and Gi proteinsPlasma membrane-associated nucleoside diphosphate kinase (nm23) in the heart is regulated by beta-adrenergic signalingI(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities.Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during beta1-adrenergic regulation.The selective anandamide transport inhibitor VDM11 attenuates reinstatement of nicotine seeking behaviour, but does not affect nicotine intakeEpinephrine Activation of the β2-Adrenoceptor Is Required for IL-13-Induced Mucin Production in Human Bronchial Epithelial Cells.beta-adrenoceptor blockers as agonists: coupling of beta2-adrenoceptors to multiple G-proteins in the failing human heart.Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice.
P2860
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P2860
Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor.
description
1995 nî lūn-bûn
@nan
1995 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի մարտին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Physiological effects of inver ...... on of the beta 2-adrenoceptor.
@ast
Physiological effects of inver ...... on of the beta 2-adrenoceptor.
@en
Physiological effects of inver ...... on of the beta 2-adrenoceptor.
@nl
type
label
Physiological effects of inver ...... on of the beta 2-adrenoceptor.
@ast
Physiological effects of inver ...... on of the beta 2-adrenoceptor.
@en
Physiological effects of inver ...... on of the beta 2-adrenoceptor.
@nl
prefLabel
Physiological effects of inver ...... on of the beta 2-adrenoceptor.
@ast
Physiological effects of inver ...... on of the beta 2-adrenoceptor.
@en
Physiological effects of inver ...... on of the beta 2-adrenoceptor.
@nl
P2093
P356
P1433
P1476
Physiological effects of inver ...... on of the beta 2-adrenoceptor.
@en
P2093
C A Milano
H A Rockman
S Apparsundaram
T D Johnson
T P Kenakin
T R McMinn
P2888
P304
P356
10.1038/374272A0
P407
P577
1995-03-01T00:00:00Z
P5875
P6179
1052817935