Interplay of physics and evolution in the likely origin of protein biochemical function
about
How special is the biochemical function of native proteins?Implications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical functionIncreasing the structural coverage of tuberculosis drug targetsA comprehensive survey of small-molecule binding pockets in proteinsSubstrate-driven mapping of the degradome by comparison of sequence logosKnowledge-based fragment binding predictionEvidence of conformational selection driving the formation of ligand binding sites in protein-protein interfacesOn the role of physics and evolution in dictating protein structure and functionPoLi: A Virtual Screening Pipeline Based on Template Pocket and Ligand Similarity.Why Is There a Glass Ceiling for Threading Based Protein Structure Prediction Methods?Are protein-protein interfaces special regions on a protein's surface?On the importance of composite protein multiple ligand interactions in protein pockets.Biophysics of protein evolution and evolutionary protein biophysicsFunctional consequences of somatic mutations in cancer using protein pocket-based prioritization approach.Catalytic and substrate promiscuity: distinct multiple chemistries catalysed by the phosphatase domain of receptor protein tyrosine phosphatase.Lessons in Protein Design from Combined Evolution and Conformational Dynamics.Comprehensive prediction of drug-protein interactions and side effects for the human proteome.Nonlinearities in protein space limit the utility of informatics in protein biophysics.Polypharmacology in Drug Development: A Minireview of Current Technologies.Discovery of inhibitors of the Wnt and Hedgehog signaling pathways through the catalytic enantioselective synthesis of an iridoid-inspired compound collection.The natural productome.Complex evolutionary footprints revealed in an analysis of reused protein segments of diverse lengths.Rational Design of Novel Allosteric Dihydrofolate Reductase Inhibitors Showing Antibacterial Effects on Drug-Resistant Escherichia coli Escape Variants.Enzyme promiscuity: using the dark side of enzyme specificity in white biotechnology
P2860
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P2860
Interplay of physics and evolution in the likely origin of protein biochemical function
description
2013 nî lūn-bûn
@nan
2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Interplay of physics and evolution in the likely origin of protein biochemical function
@ast
Interplay of physics and evolution in the likely origin of protein biochemical function
@en
Interplay of physics and evolution in the likely origin of protein biochemical function
@nl
type
label
Interplay of physics and evolution in the likely origin of protein biochemical function
@ast
Interplay of physics and evolution in the likely origin of protein biochemical function
@en
Interplay of physics and evolution in the likely origin of protein biochemical function
@nl
prefLabel
Interplay of physics and evolution in the likely origin of protein biochemical function
@ast
Interplay of physics and evolution in the likely origin of protein biochemical function
@en
Interplay of physics and evolution in the likely origin of protein biochemical function
@nl
P2860
P356
P1476
Interplay of physics and evolution in the likely origin of protein biochemical function
@en
P2093
P2860
P304
P356
10.1073/PNAS.1300011110
P407
P577
2013-05-20T00:00:00Z