Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression.
about
The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human DiseaseThe novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanomaDNA methylation characteristics of primary melanomas with distinct biological behaviour.Krüppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions.ALDH7A1 expression is associated with recurrence in patients with surgically resected non-small-cell lung carcinomaReverse engineering biomolecular systems using -omic data: challenges, progress and opportunities.The ALDH7A1 genetic polymorphisms contribute to development of esophageal squamous cell carcinoma.Melanoma risk loci as determinants of melanoma recurrence and survivalIntegrative genomics identifies gene signature associated with melanoma ulceration.BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapySuperficial spreading and nodular melanoma are distinct biological entities: a challenge to the linear progression model.RSK1 activation promotes invasion in nodular melanoma.The 3'-5' exoribonuclease Dis3 regulates the expression of specific microRNAs in Drosophila wing imaginal discs.Longitudinal analysis of 25 sequential sample-pairs using a custom multiple myeloma mutation sequencing panel (M(3)P).A new 12-gene diagnostic biomarker signature of melanoma revealed by integrated microarray analysis.FBH1 protects melanocytes from transformation and is deregulated in melanomasHistology-specific microRNA alterations in melanoma.Hedgehog pathway blockade inhibits melanoma cell growth in vitro and in vivo.Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target.N-acetylgalactosaminyltransferases in cancer.Modelling melanoma in mice.The RNase II/RNB family of exoribonucleases: putting the 'Dis' in disease.Gene-dosage dependent overexpression at the 13q amplicon identifies DIS3 as candidate oncogene in colorectal cancer progression.Functional characterization of a chr13q22.1 pancreatic cancer risk locus reveals long-range interaction and allele-specific effects on DIS3 expression.Lentivirus-mediated silencing of USO1 inhibits cell proliferation and migration of human colon cancer cells.MicroRNA-125a promotes resistance to BRAF inhibitors through suppression of the intrinsic apoptotic pathway.A genome-wide association study identifies novel single nucleotide polymorphisms associated with dermal shank pigmentation in chickens.DIS3 isoforms vary in their endoribonuclease activity and are differentially expressed within haematological cancers.
P2860
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P2860
Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression.
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
name
Integrative genomics identifie ...... model of melanoma progression.
@ast
Integrative genomics identifie ...... model of melanoma progression.
@en
Integrative genomics identifie ...... model of melanoma progression.
@nl
type
label
Integrative genomics identifie ...... model of melanoma progression.
@ast
Integrative genomics identifie ...... model of melanoma progression.
@en
Integrative genomics identifie ...... model of melanoma progression.
@nl
prefLabel
Integrative genomics identifie ...... model of melanoma progression.
@ast
Integrative genomics identifie ...... model of melanoma progression.
@en
Integrative genomics identifie ...... model of melanoma progression.
@nl
P2093
P2860
P50
P1433
P1476
Integrative genomics identifie ...... model of melanoma progression.
@en
P2093
Amy E Rose
Anna Pavlick
David Polsky
Eleazar C Vega Y Saenz de Miera
Farbod Darvishian
Guimin Wang
Harry Ostrer
Iman Osman
Jinhua Wang
Paul J Christos
P2860
P304
P356
10.1158/0008-5472.CAN-10-2958
P407
P577
2011-02-22T00:00:00Z