Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.
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Design, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate SynthaseSynthetic Procedures Leading towards AminobisphosphonatesGenetic profiling of the isoprenoid and sterol biosynthesis pathway genes of Trypanosoma cruzi2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase.The N-terminus and the chain-length determination domain play a role in the length of the isoprenoid product of the bifunctional Toxoplasma gondii farnesyl diphosphate synthase.1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthaseDesign, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents.Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity.New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase.New antibacterials for the treatment of toxoplasmosis; a patent review.Screening for small molecule inhibitors of Toxoplasma gondii.Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase.Detection and treatment of Trypanosoma cruzi: a patent review (2011-2015).Triazole-based compound as a candidate to develop novel medicines to treat toxoplasmosis.Antiparasitic Activity of Sulfur- and Fluorine-Containing Bisphosphonates against Trypanosomatids and Apicomplexan Parasites.
P2860
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P2860
Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Synthesis and biological evalu ...... farnesyl diphosphate synthase.
@ast
Synthesis and biological evalu ...... farnesyl diphosphate synthase.
@en
Synthesis and biological evalu ...... farnesyl diphosphate synthase.
@nl
type
label
Synthesis and biological evalu ...... farnesyl diphosphate synthase.
@ast
Synthesis and biological evalu ...... farnesyl diphosphate synthase.
@en
Synthesis and biological evalu ...... farnesyl diphosphate synthase.
@nl
prefLabel
Synthesis and biological evalu ...... farnesyl diphosphate synthase.
@ast
Synthesis and biological evalu ...... farnesyl diphosphate synthase.
@en
Synthesis and biological evalu ...... farnesyl diphosphate synthase.
@nl
P2093
P2860
P1476
Synthesis and biological evalu ...... farnesyl diphosphate synthase
@en
P2093
Leena Malayil
Melina Galizzi
Roberto Docampo
Silvia N J Moreno
Valeria S Rosso
P2860
P304
P356
10.1016/J.BMC.2011.02.037
P407
P577
2011-04-01T00:00:00Z