Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.
about
The P42 peptide and Peptide-based therapies for Huntington's diseaseTherapeutic targeting of autophagy in neurodegenerative and infectious diseasesTranscriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasisA Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/CScalable production in human cells and biochemical characterization of full-length normal and mutant huntingtinThe caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS productionIKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease.PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites.Does Huntingtin play a role in selective macroautophagy?Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's diseaseSox11 Reduces Caspase-6 Cleavage and Activity.An optimized activity-based probe for the study of caspase-6 activation.Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.Cerebrospinal fluid tau cleaved by caspase-6 reflects brain levels and cognition in aging and Alzheimer diseaseAn Intrabody Drug (rAAV6-INT41) Reduces the Binding of N-Terminal Huntingtin Fragment(s) to DNA to Basal Levels in PC12 Cells and Delays Cognitive Loss in the R6/2 Animal ModelPolyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk.Mitochondrial structural and functional dynamics in Huntington's disease.SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation.Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease.Screening of therapeutic strategies for Huntington's disease in YAC128 transgenic mice.Protein truncation as a common denominator of human neurodegenerative foldopathies.Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65.Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats.Novel piperazine induces apoptosis in U937 cells.More alive than dead: non-apoptotic roles for caspases in neuronal development, plasticity and disease.Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding.Changes in phosphatidylinositol 3-kinase 55 kDa gamma expression and subcellular localization may be caspase 6 dependent in paraquat-induced SH-SY5Y apoptosis.Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease.Huntington's Disease: Calcium Dyshomeostasis and Pathology ModelsModulation of mutant huntingtin N-terminal cleavage and its effect on aggregation and cell death.Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells.Ceramide phosphoethanolamine synthase SMSr is a target of caspase-6 during apoptotic cell death.Effect of methylprednisolone on the activities of caspase-3, -6, -8 and -9 in rabbits with acute spinal cord injury.
P2860
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P2860
Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Activated caspase-6 and caspas ...... lly colocalize in the nucleus.
@ast
Activated caspase-6 and caspas ...... lly colocalize in the nucleus.
@en
Activated caspase-6 and caspas ...... lly colocalize in the nucleus.
@nl
type
label
Activated caspase-6 and caspas ...... lly colocalize in the nucleus.
@ast
Activated caspase-6 and caspas ...... lly colocalize in the nucleus.
@en
Activated caspase-6 and caspas ...... lly colocalize in the nucleus.
@nl
prefLabel
Activated caspase-6 and caspas ...... lly colocalize in the nucleus.
@ast
Activated caspase-6 and caspas ...... lly colocalize in the nucleus.
@en
Activated caspase-6 and caspas ...... lly colocalize in the nucleus.
@nl
P2093
P356
P1476
Activated caspase-6 and caspas ...... lly colocalize in the nucleus.
@en
P2093
Crystal N Doty
Jeffrey B Carroll
Rona K Graham
Roshni R Singaraja
Simon C Warby
Yu-Zhou Yang
P304
P356
10.1093/HMG/DDN139
P577
2008-04-29T00:00:00Z