Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92 - Wikidata - awgldk - TriplyDB

Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92

Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92

http://www.wikidata.org/entity/Q34781384

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N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycine-induced cell migration Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects N-Arachidonyl glycine does not activate G protein-coupled receptor 18 signaling via canonical pathways Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay Orphan endogenous lipids and orphan GPCRs: a good match The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂ A novel glucagon-related peptide (GCRP) and its receptor GCRPR account for coevolution of their family members in vertebrates Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18 Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors.International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature.Feeding-dependent activation of enteric cells and sensory neurons by lymphatic fluid: evidence for a neurolymphocrine system.Inhibition of human recombinant T-type calcium channels by the endocannabinoid N-arachidonoyl dopamine.Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: synthesis of N-acyl glycinals.LPA receptor signaling: pharmacology, physiology, and pathophysiology.Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3 Lysophospholipid receptor nomenclature review: IUPHAR Review 8.A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development.Targeting TRPV3 for the Development of Novel Analgesics.Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2.A GPR18-based signalling system regulates IOP in murine eye.Aiming drug discovery at lysophosphatidic acid targets.N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn Distribution of endogenous farnesyl pyrophosphate and four species of lysophosphatidic acid in rodent brain.Insights into the pharmacological relevance of lysophospholipid receptors.Peripheral neural targets in obesity So what do we call GPR18 now?N-Arachidonoyl glycine suppresses Na⁺/Ca²⁺ exchanger-mediated Ca²⁺ entry into endothelial cells and activates BK(Ca) channels independently of GPCRs.Cannabinoids, endocannabinoids, and related analogs in inflammation Genetic and pharmacological evidence for low-abundance TRPV3 expression in primary vagal afferent neurons.P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion.Intercellular Lipid Mediators and GPCR Drug Discovery N-acyl amino acids and N-acyl neurotransmitter conjugates: neuromodulators and probes for new drug targets.Fatty acid amide signaling molecules.Endocannabinoids, related compounds and their metabolic routes.G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction.The effects of direct inhibition of geranylgeranyl pyrophosphate synthase on osteoblast differentiation.Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist.

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Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92

http://www.wikidata.org/entity/Q34781384

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2008 nî lūn-bûn

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2008 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2008 թվականի մայիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Identification of farnesyl pyr ...... s endogenous ligands for GPR92

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Identification of farnesyl pyr ...... s endogenous ligands for GPR92

@en

Identification of farnesyl pyr ...... s endogenous ligands for GPR92

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label

Identification of farnesyl pyr ...... s endogenous ligands for GPR92

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Identification of farnesyl pyr ...... s endogenous ligands for GPR92

@en

Identification of farnesyl pyr ...... s endogenous ligands for GPR92

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prefLabel

Identification of farnesyl pyr ...... s endogenous ligands for GPR92

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Identification of farnesyl pyr ...... s endogenous ligands for GPR92

@en

Identification of farnesyl pyr ...... s endogenous ligands for GPR92

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Journal of Biological Chemistry

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Identification of farnesyl pyr ...... s endogenous ligands for GPR92

@en

P2093

Da Young Oh

http://www.w3.org/2001/XMLSchema#string

David K O'Dell

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Han Choe

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Heung Sik Na

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Hyewhon Rhim

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Hyuk Bang Kwon

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J Michael Walker

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Jae Il Kim

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Jae Young Seong

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Jong-Ik Hwang

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P2860

A capsaicin-receptor homologue with a high threshold for noxious heat

Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis

Structure of mammalian protein geranylgeranyltransferase type-I

The G protein-coupled receptor repertoires of human and mouse

Actions of N-arachidonyl-glycine in a rat inflammatory pain model

Discovery and mapping of ten novel G protein-coupled receptor genes

Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family

Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes

GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5

Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18

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21054-21064

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scholarly article

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10.1074/JBC.M708908200

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30

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283

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2008-05-22T00:00:00Z

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18499677

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2475705

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