NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity. - Wikidata - awgldk - TriplyDB

NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity.

NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity.

http://www.wikidata.org/entity/Q34782190

about

Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes PLC-γ directly binds activated c-Src, which is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe cells NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol.Myosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells.Roles for NHERF1 and NHERF2 on the regulation of C3a receptor signaling in human mast cells Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation site Chloride channel (Clc)-5 is necessary for exocytic trafficking of Na+/H+ exchanger 3 (NHE3).NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum.Evidence for a causal link between adaptor protein PDZK1 downregulation and Na⁺/H⁺ exchanger NHE3 dysfunction in human and murine colitis Elevated calcium acutely regulates dynamic interactions of NHERF2 and NHE3 proteins in opossum kidney (OK) cell microvilli.An old herbal medicine with a potentially new therapeutic application in inflammatory bowel disease.Small intestinal ion transport.Sorting nexin 27 regulates basal and stimulated brush border trafficking of NHE3.Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.The NHERF2 sequence adjacent and upstream of the ERM-binding domain affects NHERF2-ezrin binding and dexamethasone stimulated NHE3 activity.Na-H Exchanger Isoform-2 (NHE2) Mediates Butyrate-dependent Na+ Absorption in Dextran Sulfate Sodium (DSS)-induced Colitis Regulation of expression and function of scavenger receptor class B, type I (SR-BI) by Na+/H+ exchanger regulatory factors (NHERFs)Rapamycin Inhibition of mTOR Reduces Levels of the Na+/H+ Exchanger 3 in Intestines of Mice and Humans, Leading to Diarrhea.NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells.Traditional and emerging roles for the SLC9 Na+/H+ exchangers.PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class I PDZ-binding motifs.Regulation of Transporters and Channels by Membrane-Trafficking Complexes in Epithelial Cells.Carbachol-mediated endocytosis of NHE3 involves a clathrin-independent mechanism requiring lipid rafts and Cdc42.Phosphorylation of NHE3-S719 regulates NHE3 activity through the formation of multiple signaling complexes.Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca(2+), cGMP and lysophosphatidic acid.Phosphorylation and subcellular localization of Na+/H+ exchanger isoform 3 (NHE3) are associated with altered gallbladder absorptive function after formation of cholesterol gallstones.A role of intestine in hypertension: mechanism of suppression of intestinal Na-H exchanger isoform-3 in spontaneously hypertensive rats

P2860

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P2860

NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity.

http://www.wikidata.org/entity/Q34782190

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

NHERF1 and NHERF2 are necessar ...... e regulation of NHE3 activity.

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NHERF1 and NHERF2 are necessar ...... e regulation of NHE3 activity.

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NHERF1 and NHERF2 are necessar ...... e regulation of NHE3 activity.

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type

label

NHERF1 and NHERF2 are necessar ...... e regulation of NHE3 activity.

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NHERF1 and NHERF2 are necessar ...... e regulation of NHE3 activity.

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NHERF1 and NHERF2 are necessar ...... e regulation of NHE3 activity.

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prefLabel

NHERF1 and NHERF2 are necessar ...... e regulation of NHE3 activity.

@ast

NHERF1 and NHERF2 are necessar ...... e regulation of NHE3 activity.

@en

NHERF1 and NHERF2 are necessar ...... e regulation of NHE3 activity.

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P356

AJPCELL.00119.2010

P1433

American Journal of Physiology - Cell Physiology

P1476

NHERF1 and NHERF2 are necessar ...... e regulation of NHE3 activity.

@en

P2093

Boris Hogema

http://www.w3.org/2001/XMLSchema#string

Boyoung Cha

http://www.w3.org/2001/XMLSchema#string

Hugo de Jonge

http://www.w3.org/2001/XMLSchema#string

Mark Donowitz

http://www.w3.org/2001/XMLSchema#string

Mirza Zizak

http://www.w3.org/2001/XMLSchema#string

Nicholas C Zachos

http://www.w3.org/2001/XMLSchema#string

Rafiquel Sarker

http://www.w3.org/2001/XMLSchema#string

Rong Lin

http://www.w3.org/2001/XMLSchema#string

Sandra Guggino

http://www.w3.org/2001/XMLSchema#string

Tian-e Chen

http://www.w3.org/2001/XMLSchema#string

P2860

Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis

Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets

The down regulated in adenoma (dra) gene product binds to the second PDZ domain of the NHE3 kinase A regulatory protein (E3KARP), potentially linking intestinal Cl-/HCO3- exchange to Na+/H+ exchange

cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein

A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor

Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling

Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2

Na+-H+ exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: a role for rafts in trafficking and rapid stimulation of NHE3

Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting

NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes

P304

C771-82

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scholarly article

P356

10.1152/AJPCELL.00119.2010

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4

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300

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2010-12-29T00:00:00Z

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21191106

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3074635

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