Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction.
about
Mutations in myosin light chain kinase cause familial aortic dissectionsTreatment guidelines for thoracic aortic aneurysms and dissections based on the underlying causative geneSuccesses and challenges of using whole exome sequencing to identify novel genes underlying an inherited predisposition for thoracic aortic aneurysms and acute aortic dissectionsThe role of mechanotransduction on vascular smooth muscle myocytes' [corrected] cytoskeleton and contractile functionMyh11(R247C/R247C) mutations increase thoracic aorta vulnerability to intramural damage despite a general biomechanical adaptivity.Vascular disease-causing mutation R258C in ACTA2 disrupts actin dynamics and interaction with myosinα-Smooth Muscle Actin and ACTA2 Gene Expressions in VasculopathiesStructure of the F-actin-tropomyosin complexParental somatic mosaicism is underrecognized and influences recurrence risk of genomic disordersNew Insights Into Aortic Diseases: A Report From the Third International Meeting on Aortic Diseases (IMAD3)Aortic dilatation in children with systemic hypertension.Bone marrow-derived MCP1 required for experimental aortic aneurysm formation and smooth muscle phenotypic modulation.Incomplete segregation of MYH11 variants with thoracic aortic aneurysms and dissections and patent ductus arteriosus.Deletion of Dicer in somatic cells of the female reproductive tract causes sterility.Pharmacologically Improved Contractility Protects Against Aortic Dissection in Mice With Disrupted Transforming Growth Factor-β Signaling Despite Compromised Extracellular Matrix Properties.Consistent biomechanical phenotyping of common carotid arteries from seven genetic, pharmacological, and surgical mouse models.Genetic analysis of six SNPs in candidate genes associated with high cross-race risk of development of thoracic aortic aneurysms and dissections in Chinese Han populationDifference in hemodynamic and wall stress of ascending thoracic aortic aneurysms with bicuspid and tricuspid aortic valveLong-term miR-29b suppression reduces aneurysm formation in a Marfan mouse model.Overexpression of smooth muscle myosin heavy chain leads to activation of the unfolded protein response and autophagic turnover of thick filament-associated proteins in vascular smooth muscle cellsFibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progressionA balanced translocation truncates Neurotrimin in a family with intracranial and thoracic aortic aneurysmA 1-bp duplication in TGFB2 in three family members with a syndromic form of thoracic aortic aneurysm.Non-coding RNA Contribution to Thoracic and Abdominal Aortic Aneurysm Disease Development and Progression.S100A12 mediates aortic wall remodeling and aortic aneurysm.Coupling hemodynamics with vascular wall mechanics and mechanobiology to understand intracranial aneurysms.Induction of macrophage chemotaxis by aortic extracts from patients with Marfan syndrome is related to elastin binding protein.Recurrent chromosome 16p13.1 duplications are a risk factor for aortic dissections.Characterization of large genomic deletions in the FBN1 gene using multiplex ligation-dependent probe amplification.Smad2 and myocardin-related transcription factor B cooperatively regulate vascular smooth muscle differentiation from neural crest cells.The genetic basis of aortic aneurysmBicuspid aortic valve: identifying knowledge gaps and rising to the challenge from the International Bicuspid Aortic Valve Consortium (BAVCon).Serum proteomic signature of human chagasic patients for the identification of novel potential protein biomarkers of disease.TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections.Rare copy number variants disrupt genes regulating vascular smooth muscle cell adhesion and contractility in sporadic thoracic aortic aneurysms and dissectionsEpigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms.Causes and histopathology of ascending aortic disease in children and young adults.Alternative splicing impairs soluble guanylyl cyclase function in aortic aneurysmMFAP5 loss-of-function mutations underscore the involvement of matrix alteration in the pathogenesis of familial thoracic aortic aneurysms and dissectionsAllele-specific effects of thoracic aortic aneurysm and dissection alpha-smooth muscle actin mutations on actin function
P2860
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P2860
Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Genetic basis of thoracic aort ...... cell contractile dysfunction.
@ast
Genetic basis of thoracic aort ...... cell contractile dysfunction.
@en
Genetic basis of thoracic aort ...... cell contractile dysfunction.
@nl
type
label
Genetic basis of thoracic aort ...... cell contractile dysfunction.
@ast
Genetic basis of thoracic aort ...... cell contractile dysfunction.
@en
Genetic basis of thoracic aort ...... cell contractile dysfunction.
@nl
prefLabel
Genetic basis of thoracic aort ...... cell contractile dysfunction.
@ast
Genetic basis of thoracic aort ...... cell contractile dysfunction.
@en
Genetic basis of thoracic aort ...... cell contractile dysfunction.
@nl
P2093
P1476
Genetic basis of thoracic aort ...... cell contractile dysfunction.
@en
P2093
Andrea L Lafont
Carrie S Kwartler
Christina L Papke
Dianna M Milewicz
Dong-Chuan Guo
Hariyadarshi Pannu
Sakiko Inamoto
Van Tran-Fadulu
P304
P356
10.1146/ANNUREV.GENOM.8.080706.092303
P577
2008-01-01T00:00:00Z