An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors.
about
Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteriaGenome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistanceRibosomal Antibiotics: Contemporary ChallengesResistance to linezolid caused by modifications at its binding site on the ribosomeStructures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug actionCrystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNAStructure of the E. coli ribosome-EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EMTranscriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA.Base methylations in the double-stranded RNA by a fused methyltransferase bearing unwinding activityMutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance.Inactivation of the indigenous methyltransferase RlmN in Staphylococcus aureus increases linezolid resistanceNucleic Acid Modifications in Regulation of Gene Expression.Structural basis for cross-resistance to ribosomal PTC antibiotics.Macrolide antibiotics in the ribosome exit tunnel: species-specific binding and action.Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin.Linezolid Resistance in Staphylococci.How much can we learn about the function of bacterial rRNA modification by mining large-scale experimental datasets?Pseudouridine-Free Escherichia coli Ribosomes.
P2860
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P2860
An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
An indigenous posttranscriptio ...... protein synthesis inhibitors.
@ast
An indigenous posttranscriptio ...... protein synthesis inhibitors.
@en
An indigenous posttranscriptio ...... protein synthesis inhibitors.
@nl
type
label
An indigenous posttranscriptio ...... protein synthesis inhibitors.
@ast
An indigenous posttranscriptio ...... protein synthesis inhibitors.
@en
An indigenous posttranscriptio ...... protein synthesis inhibitors.
@nl
prefLabel
An indigenous posttranscriptio ...... protein synthesis inhibitors.
@ast
An indigenous posttranscriptio ...... protein synthesis inhibitors.
@en
An indigenous posttranscriptio ...... protein synthesis inhibitors.
@nl
P2860
P1476
An indigenous posttranscriptio ...... protein synthesis inhibitors.
@en
P2093
Alexander S Mankin
Seok-Ming Toh
P2860
P304
P356
10.1016/J.JMB.2008.05.027
P407
P577
2008-05-17T00:00:00Z