FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity.
about
FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacologyEnhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplantsExit Strategies: S1P Signaling and T Cell MigrationLipid receptor S1P₁ activation scheme concluded from microsecond all-atom molecular dynamics simulationsEffector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunityDelivery of S1P receptor-targeted drugs via biodegradable polymer scaffolds enhances bone regeneration in a critical size cranial defect.Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors.Tumor masses support naive T cell infiltration, activation, and differentiation into effectorsStrategies and challenges in eliciting immunity to melanoma.Activated CD8 T cells redistribute to antigen-free lymph nodes and exhibit effector and memory characteristics.Targeting sphingosine 1 phosphate receptor type 1 receptors in acute kidney injury.The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches.Biological roles of lysophospholipid receptors revealed by genetic null mice: an update.Identification of the hydrophobic ligand binding pocket of the S1P1 receptorDeliberate fingolimod overdose presenting with delayed hypotension and bradycardia responsive to atropine.Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes.Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organsBlood sphingolipidomics in healthy humans: impact of sample collection methodology.Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung.Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.Lymphocyte modulation with FTY720 improves hemorrhagic shock survival in swineThe immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2.A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin.Anti-inflammatory effects of FTY720 do not prevent neuronal cell loss in a rat model of optic neuritis.Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model.Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory systemTherapeutic use of a selective S1P1 receptor modulator ponesimod in autoimmune diabetesS1P is associated with protection in human and experimental cerebral malariaFTY720: A new kid on the block for transplant immunosuppression.Immunosuppressants in advanced clinical development for organ transplantation and selected autoimmune diseases.Discovery of new G protein-coupled receptors for lipid mediators.Sphingosine 1-phosphate and its type 1 G protein-coupled receptor: trophic support and functional regulation of T lymphocytes.FTY720 in multiple sclerosis: the emerging evidence of its therapeutic value.Targeting tubulointerstitial remodeling in proteinuric nephropathy in ratsRegulation of immunity by lysosphingolipids and their G protein-coupled receptorsRapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonistHPTLC-MALDI MS for (glyco)sphingolipid multiplexing in tissues and blood: A promising strategy for biomarker discovery and clinical applications.Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric ArteriesThe sphingosine-1-phosphate analogue FTY720 impairs mucosal immunity and clearance of the enteric pathogen Citrobacter rodentium.Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins
P2860
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P2860
FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity.
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
FTY720: targeting G-protein-co ...... nsplantation and autoimmunity.
@ast
FTY720: targeting G-protein-co ...... nsplantation and autoimmunity.
@en
FTY720: targeting G-protein-co ...... nsplantation and autoimmunity.
@nl
type
label
FTY720: targeting G-protein-co ...... nsplantation and autoimmunity.
@ast
FTY720: targeting G-protein-co ...... nsplantation and autoimmunity.
@en
FTY720: targeting G-protein-co ...... nsplantation and autoimmunity.
@nl
prefLabel
FTY720: targeting G-protein-co ...... nsplantation and autoimmunity.
@ast
FTY720: targeting G-protein-co ...... nsplantation and autoimmunity.
@en
FTY720: targeting G-protein-co ...... nsplantation and autoimmunity.
@nl
P1476
FTY720: targeting G-protein-co ...... nsplantation and autoimmunity.
@en
P2093
Kevin R Lynch
Volker Brinkmann
P304
P356
10.1016/S0952-7915(02)00374-6
P577
2002-10-01T00:00:00Z