The heparin-binding domain of IGFBP-2 has insulin-like growth factor binding-independent biologic activity in the growing skeleton
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Brown adipose tissue and bonePartial agonist, telmisartan, maintains PPARγ serine 112 phosphorylation, and does not affect osteoblast differentiation and bone massExogenous IGFBP-2 promotes proliferation, invasion, and chemoresistance to temozolomide in glioma cells via the integrin β1-ERK pathwayInsulin growth factor binding protein 2 mediates the progression of lymphangioleiomyomatosis.Insulin-like growth factor (IGF) signaling in tumorigenesis and the development of cancer drug resistance.IGFBP-2 - taking the lead in growth, metabolism and cancerInsulin-like growth factor-binding protein-2 is required for osteoclast differentiation.Insulin-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase β and the IGF-I receptor to regulate IGF-I-stimulated signaling.IGFBP2 modulates the chemoresistant phenotype in esophageal adenocarcinoma.IGF-I and IGFBP-2 Stimulate AMPK Activation and Autophagy, Which Are Required for Osteoblast DifferentiationInducible brown adipose tissue, or beige fat, is anabolic for the skeleton.The heparin-binding domains of IGFBP-2 mediate its inhibitory effect on preadipocyte differentiation and fat development in male mice.IGFBP2/FAK pathway is causally associated with dasatinib resistance in non-small cell lung cancer cells.IGFBP-2 directly stimulates osteoblast differentiation.The C-terminus of IGFBP-5 suppresses tumor growth by inhibiting angiogenesisIRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation.Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity.Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profilesThe skeleton: a multi-functional complex organ: new insights into osteoblasts and their role in bone formation: the central role of PI3Kinase.Signaling pathways affecting skeletal health.Insulin/IGF signaling in Drosophila and other insects: factors that regulate production, release and post-release action of the insulin-like peptides.IGF-binding protein 2 is a candidate target of therapeutic potential in cancer.FGF23 suppresses chondrocyte proliferation in the presence of soluble α-Klotho both in vitro and in vivo.Insulin- like Growth Factor-Binding Protein Action in Bone Tissue: A Key Role for Pregnancy- Associated Plasma Protein-A.A peptide containing the receptor binding site of insulin-like growth factor binding protein-2 enhances bone mass in ovariectomized rats
P2860
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P2860
The heparin-binding domain of IGFBP-2 has insulin-like growth factor binding-independent biologic activity in the growing skeleton
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The heparin-binding domain of ...... tivity in the growing skeleton
@ast
The heparin-binding domain of ...... tivity in the growing skeleton
@en
The heparin-binding domain of ...... tivity in the growing skeleton
@nl
type
label
The heparin-binding domain of ...... tivity in the growing skeleton
@ast
The heparin-binding domain of ...... tivity in the growing skeleton
@en
The heparin-binding domain of ...... tivity in the growing skeleton
@nl
prefLabel
The heparin-binding domain of ...... tivity in the growing skeleton
@ast
The heparin-binding domain of ...... tivity in the growing skeleton
@en
The heparin-binding domain of ...... tivity in the growing skeleton
@nl
P2093
P2860
P356
P1476
The heparin-binding domain of ...... tivity in the growing skeleton
@en
P2093
Anne C Breggia
Clifford J Rosen
David R Clemmons
Ernesto Canalis
Masanobu Kawai
Victoria E DeMambro
Wesley G Beamer
Xinchun Shen
P2860
P304
14670-14680
P356
10.1074/JBC.M110.193334
P407
P577
2011-03-03T00:00:00Z