A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
about
Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.The integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell.A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and plateletsTargeting leukocyte integrins in human diseasesNeutrophil cell surface receptors and their intracellular signal transduction pathways.Involvement of raft-like plasma membrane domains of Entamoeba histolytica in pinocytosis and adhesion.Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18Qualitative disorders of platelets and megakaryocytes.High-throughput screening based identification of small molecule antagonists of integrin CD11b/CD18 ligand binding.Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo.Disabling multiple integrins from the inside out.Integrins in regulation of tissue development and function.Integrin-dependent pathologies.The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2.Leukocyte adhesion deficiency-I variant syndrome (LAD-Iv, LAD-III): molecular characterization of the defect in an index familyLessons from rare maladies: leukocyte adhesion deficiency syndromes.Novel aspects of Kindlin-3 function in humans based on a new case of leukocyte adhesion deficiency III.Interfering with leukocyte integrin activation--a novel concept in the development of anti-inflammatory drugs.The role of the integrin LFA-1 in T-lymphocyte migration.Defects in the leukocyte adhesion cascade.Hematopoetic stem cell transplantation in neutrophil disorders: severe congenital neutropenia, leukocyte adhesion deficiency and chronic granulomatous disease.Kindling the flame of integrin activation and function with kindlinsMolecular regulators of leucocyte chemotaxis during inflammation.Kindlins in FERM adhesion.Recent advances in the understanding of genetic defects of neutrophil number and function.Leukocyte adhesion deficiency III - when integrins activation fails.Transmembrane helices that form two opposite homodimeric interactions: an asparagine scan study of alphaM and beta2 integrins.Competition for talin results in trans-dominant inhibition of integrin activation.Leukocyte adhesion deficiency-III in an African-American patient.The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate beta1 and beta3 integrins.
P2860
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P2860
A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
@ast
A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
@en
A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
@nl
type
label
A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
@ast
A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
@en
A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
@nl
prefLabel
A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
@ast
A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
@en
A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
@nl
P2093
P2860
P356
P1476
A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
@en
P2093
Alison Jones
Alison McDowall
Birgit Leitinger
David Inwald
Nancy Hogg
Nigel Klein
Ri Liesner
P2860
P356
10.1172/JCI200314076
P407
P577
2003-01-01T00:00:00Z