Non-nucleoside HIV-1 reverse transcriptase inhibitors di-halo-indolyl aryl sulfones achieve tight binding to drug-resistant mutants by targeting the enzyme-substrate complex.

Non-nucleoside HIV-1 reverse transcriptase inhibitors di-halo-indolyl aryl sulfones achieve tight binding to drug-resistant mutants by targeting the enzyme-substrate complex.

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http://www.wikidata.org/entity/Q34872382
A novel molecular mechanism of dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors.Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.The "Connection" Between HIV Drug Resistance and RNase HRh2(II)-catalyzed nitro-group migration reactions: selective synthesis of 3-nitroindoles from β-nitro styryl azidesArylsulfone-based HIV-1 non-nucleoside reverse transcriptase inhibitors.Mechanism of interaction of novel indolylarylsulfone derivatives with K103N and Y181I mutant HIV-1 reverse transcriptase in complex with its substrates.Novel fluorine-containing DAPY derivatives as potent HIV-1 NNRTIs: a patent evaluation of WO2014072419.Indolylarylsulfones, a fascinating story of highly potent human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors.HIV Reverse Transcriptase Inhibitors
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Non-nucleoside HIV-1 reverse transcriptase inhibitors di-halo-indolyl aryl sulfones achieve tight binding to drug-resistant mutants by targeting the enzyme-substrate complex.

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http://www.wikidata.org/entity/Q34872382
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Non-nucleoside HIV-1 reverse t ...... the enzyme-substrate complex.
@ast
Non-nucleoside HIV-1 reverse t ...... the enzyme-substrate complex.
@en
Non-nucleoside HIV-1 reverse t ...... the enzyme-substrate complex.
@nl
type
label
Non-nucleoside HIV-1 reverse t ...... the enzyme-substrate complex.
@ast
Non-nucleoside HIV-1 reverse t ...... the enzyme-substrate complex.
@en
Non-nucleoside HIV-1 reverse t ...... the enzyme-substrate complex.
@nl
prefLabel
Non-nucleoside HIV-1 reverse t ...... the enzyme-substrate complex.
@ast
Non-nucleoside HIV-1 reverse t ...... the enzyme-substrate complex.
@en
Non-nucleoside HIV-1 reverse t ...... the enzyme-substrate complex.
@nl
P1433
P1476
P2093
P304
P31
P356
P433
P478
P577
P698
P356
P1433
P1476
Non-nucleoside HIV-1 reverse t ...... the enzyme-substrate complex.
@en
P2093
P304
P31
P356
10.1016/J.ANTIVIRAL.2008.09.008
P433
P478
P577
P698