Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw. - Wikidata - awgldk - TriplyDB

Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw.

Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw.

http://www.wikidata.org/entity/Q34934330

about

From animal models to human disease: a genetic approach for personalized medicine in ALS Current progress of genetically engineered pig models for biomedical research Development of transgenic minipigs with expression of antimorphic human cryptochrome 1 Germline transgenic pigs by Sleeping Beauty transposition in porcine zygotes and targeted integration in the pig genome Transgenesis for pig models Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human β1 and α2 integrin Animal models for Alzheimer's disease and frontotemporal dementia: a perspective Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set.Genetically modified pig models for neurodegenerative disorders.Factors Determining the Efficiency of Porcine Somatic Cell Nuclear Transfer: Data Analysis with Over 200,000 Reconstructed Embryos.Tissue-specific expression and regulatory networks of pig microRNAome.Determination of odor detection threshold in the Gottingen minipig.Application of immunohistochemistry in stereology for quantitative assessment of neural cell populations illustrated in the Göttingen minipig.Handmade cloned transgenic sheep rich in omega-3 Fatty acids.Generation of interleukin-2 receptor gamma gene knockout pigs from somatic cells genetically modified by zinc finger nuclease-encoding mRNA Genetically engineered pig models for human diseases.Adult porcine genome-wide DNA methylation patterns support pigs as a biomedical model.Production of transgenic cloned pigs expressing the far-red fluorescent protein monomeric Plum.Early aberrations in chromatin dynamics in embryos produced under in vitro conditions.Handmade cloned transgenic piglets expressing the nematode fat-1 gene Impaired APP activity and altered Tau splicing in embryonic stem cell-derived astrocytes obtained from an APPsw transgenic minipig.Genetic modifications of pigs for medicine and agriculture.Computational Prediction of Alzheimer's and Parkinson's Disease MicroRNAs in Domestic Animals Germline modification of domestic animals.Porcine synapsin 1: SYN1 gene analysis and functional characterization of the promoter.Systems biology approach to the dissection of the complexity of regulatory networks in the S. scrofa cardiocirculatory system.Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs.Assessment of fecundity and germ line transmission in two transgenic pig lines produced by sleeping beauty transposition.High-level recombinant human lysozyme expressed in milk of transgenic pigs can inhibit the growth of Escherichia coli in the duodenum and influence intestinal morphology of sucking pigs.The transgenic cloned pig population with integrated and controllable GH expression that has higher feed efficiency and meat production.Advances in porcine genomics and proteomics--a toolbox for developing the pig as a model organism for molecular biomedical research.Modeling human neurodegenerative diseases in transgenic systems.Genetically modified pigs for biomedical research.Domestic animal models for biomedical research.Somatic cell nuclear transfer cloning: practical applications and current legislation.Genetically modified pigs to model human diseases.Pig models of neurodegenerative disorders: Utilization in cell replacement-based preclinical safety and efficacy studies.The pig as an animal model for human pathologies: A proteomics perspective.Porcine models of cutaneous wound healing.Genetically engineered livestock for biomedical models.

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Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw.

http://www.wikidata.org/entity/Q34934330

description

2009 nî lūn-bûn

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2009 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հունվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Hemizygous minipigs produced b ...... using dominant mutation APPsw.

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Hemizygous minipigs produced b ...... using dominant mutation APPsw.

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Hemizygous minipigs produced b ...... using dominant mutation APPsw.

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type

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Hemizygous minipigs produced b ...... using dominant mutation APPsw.

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Hemizygous minipigs produced b ...... using dominant mutation APPsw.

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Hemizygous minipigs produced b ...... using dominant mutation APPsw.

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Hemizygous minipigs produced b ...... using dominant mutation APPsw.

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Hemizygous minipigs produced b ...... using dominant mutation APPsw.

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Hemizygous minipigs produced b ...... using dominant mutation APPsw.

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Transgenic Research

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Hemizygous minipigs produced b ...... using dominant mutation APPsw.

@en

P2093

Arne Lund Jørgensen

http://www.w3.org/2001/XMLSchema#string

Gábor Vajta

http://www.w3.org/2001/XMLSchema#string

Ida E Holm

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Ingrid Brück Bøgh

http://www.w3.org/2001/XMLSchema#string

Jannik E Jakobsen

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Juan Li

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Marianne G Johansen

http://www.w3.org/2001/XMLSchema#string

Mette Schmidt

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Peter M Kragh

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Stig Purup

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P2860

Long-term accumulation of amyloid-beta, beta-secretase, presenilin-1, and caspase-3 in damaged axons following brain trauma

Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.

The fetal and neonatal pig in biomedical research.

Porcine APP cDNAs: molecular cloning and characterization, expression analysis, chromosomal localization and SNP analysis.

Neuropathological changes in Down's syndrome hippocampal formation. Effect of age and apolipoprotein E genotype.

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s11248-009-9245-4

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10.1007/S11248-009-9245-4

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4

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18

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2009-01-29T00:00:00Z

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19184503

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P921

Alzheimer's disease