Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. - Wikidata - awgldk - TriplyDB

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin.

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin.

http://www.wikidata.org/entity/Q34938493

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Radical-mediated enzymatic carbon chain fragmentation-recombination Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria Cyclisation mechanisms in the biosynthesis of ribosomally synthesised and post-translationally modified peptides The skin microbiome: a focus on pathogens and their association with skin disease Thiopeptide antibiotics: retrospective and recent advances Lessons learned from the transformation of natural product discovery to a genome-driven endeavor ThioFinder: a web-based tool for the identification of thiopeptide gene clusters in DNA sequences Comparative genomics and transcriptomics of Propionibacterium acnes Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining Genome mining demonstrates the widespread occurrence of gene clusters encoding bacteriocins in cyanobacteria.Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family Plantazolicin, a novel microcin B17/streptolysin S-like natural product from Bacillus amyloliquefaciens FZB42.A simple reverse genetics approach to elucidating the biosynthetic pathway of nocathiacin.In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria.Identification and analysis of the biosynthetic gene cluster encoding the thiopeptide antibiotic cyclothiazomycin in Streptomyces hygroscopicus 10-22.Biosynthesis and regulation of grisemycin, a new member of the linaridin family of ribosomally synthesized peptides produced by Streptomyces griseus IFO 13350.Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses.Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants.Natural products version 2.0: connecting genes to molecules.Genetic interception and structural characterization of thiopeptide cyclization precursors from Bacillus cereus.Thiazolyl peptide antibiotic biosynthesis: a cascade of post-translational modifications on ribosomal nascent proteins.Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum.Production of a new thiopeptide antibiotic, TP-1161, by a marine Nocardiopsis species.Catalysis at the intersection of biology, chemistry, and medicine.Genome mining for ribosomally synthesized natural products Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics.Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics.YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations.Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.Microbial genomics and infectious diseases.In vitro activity of the nisin dehydratase NisB.Genomic basis for natural product biosynthetic diversity in the actinomycetes Structure and mechanism of lanthipeptide biosynthetic enzymes.Bacterial skin commensals and their role as host guardians.Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans.Thiopeptide antibiotics stimulate biofilm formation in Bacillus subtilis.Complete genome sequence of the filamentous gliding predatory bacterium Herpetosiphon aurantiacus type strain (114-95(T)).Identification and classification of known and putative antimicrobial compounds produced by a wide variety of Bacillales species.Natural products as mediators of disease.

P2860

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P2860

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin.

http://www.wikidata.org/entity/Q34938493

description

2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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Thirteen posttranslational mod ...... nto the antibiotic thiocillin.

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Thirteen posttranslational mod ...... nto the antibiotic thiocillin.

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Thirteen posttranslational mod ...... nto the antibiotic thiocillin.

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Thirteen posttranslational mod ...... nto the antibiotic thiocillin.

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Thirteen posttranslational mod ...... nto the antibiotic thiocillin.

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PNAS.0900008106

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Proceedings of the National Academy of Sciences of the United States of America

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Thirteen posttranslational mod ...... into the antibiotic thiocillin

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P2093

Christopher T Walsh

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Jon Clardy

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Laura C Wieland Brown

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P2860

Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella

Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin

YM-266183 and YM-266184, novel thiopeptide antibiotics produced by Bacillus cereus isolated from a marine sponge II. Structure elucidation.

Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production.

Biosynthesis and genetic engineering of lipopeptide antibiotics related to daptomycin.

A global assembly line for cyanobactins

Biosynthesis of nonribosomal peptides1.

Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines.

Thiopeptide antibiotics.

Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

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2549-2553

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scholarly article

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8

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106

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Michael A. Fischbach

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2009-02-05T00:00:00Z

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23983332

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19196969

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2650375

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