Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis - Wikidata - awgldk - TriplyDB

Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis

Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis

http://www.wikidata.org/entity/Q34944999

about

A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α Role of Receptor Tyrosine Kinase Signaling in Renal Fibrosis Structural and functional properties of platelet-derived growth factor and stem cell factor receptors Developmental origin and lineage plasticity of endogenous cardiac stem cells Animal models of systemic sclerosis: their utility and limitations.Genetic tools for identifying and manipulating fibroblasts in the mouse Phf14, a novel regulator of mesenchyme growth via platelet-derived growth factor (PDGF) receptor-α B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin Detrimental effects of duplicate reads and low complexity regions on RNA- and ChIP-seq data.Frequent activation of EGFR in advanced chordomas.Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth.PDGFRβ signaling regulates mural cell plasticity and inhibits fat development.Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle.Pericytes at the intersection between tissue regeneration and pathology.Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit.Low/negative expression of PDGFR-α identifies the candidate primary mesenchymal stromal cells in adult human bone marrow.Coagulation and autoimmunity in scleroderma interstitial lung disease.Experimentally-derived fibroblast gene signatures identify molecular pathways associated with distinct subsets of systemic sclerosis patients in three independent cohorts.Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis Myospheres are composed of two cell types: one that is myogenic and a second that is mesenchymal Epitope Specificity Determines Pathogenicity and Detectability of Anti-Platelet-Derived Growth Factor Receptor α Autoantibodies in Systemic Sclerosis.PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity PDGFRα plays a crucial role in connective tissue remodeling.ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers.Imatinib attenuates cardiac fibrosis by inhibiting platelet-derived growth factor receptors activation in isoproterenol induced model.Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration Adipogenic role of alternatively activated macrophages in β-adrenergic remodeling of white adipose tissue.Diversity of Interstitial Lung Fibroblasts Is Regulated by Platelet-Derived Growth Factor Receptor α Kinase Activity Cellular mechanisms of tissue fibrosis. 4. Structural and functional consequences of skeletal muscle fibrosis Enpp2/Autotaxin in dermal papilla precursors is dispensable for hair follicle morphogenesis Coronary adventitial cells are linked to perivascular cardiac fibrosis via TGFβ1 signaling in the mdx mouse model of Duchenne muscular dystrophy.Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle.Roles of nonmyogenic mesenchymal progenitors in pathogenesis and regeneration of skeletal muscle.Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities.Non-myogenic Contribution to Muscle Development and Homeostasis: The Role of Connective Tissues.Identification and characterization of PDGFRα+ mesenchymal progenitors in human skeletal muscle.Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis.Cell-extracellular matrix interactions in normal and diseased skin.Resident mesenchymal cells and fibrosis.Involvement of PDGF in fibrosis and scleroderma: recent insights from animal models and potential therapeutic opportunities

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P2860

Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis

http://www.wikidata.org/entity/Q34944999

description

2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Increased PDGFRalpha activatio ...... t and drives systemic fibrosis

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Increased PDGFRalpha activatio ...... t and drives systemic fibrosis

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Increased PDGFRalpha activatio ...... t and drives systemic fibrosis

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type

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Increased PDGFRalpha activatio ...... t and drives systemic fibrosis

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Increased PDGFRalpha activatio ...... t and drives systemic fibrosis

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Increased PDGFRalpha activatio ...... t and drives systemic fibrosis

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prefLabel

Increased PDGFRalpha activatio ...... t and drives systemic fibrosis

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Increased PDGFRalpha activatio ...... t and drives systemic fibrosis

@en

Increased PDGFRalpha activatio ...... t and drives systemic fibrosis

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J.DEVCEL.2008.12.003

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Developmental Cell

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Increased PDGFRalpha activatio ...... t and drives systemic fibrosis

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Lorin E Olson

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P2860

Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney

Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma

Senescence of activated stellate cells limits liver fibrosis

Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.

PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib.

Generalized lacZ expression with the ROSA26 Cre reporter strain

Hedgehog signals regulate multiple aspects of gastrointestinal development

The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions

Tbx18 regulates the development of the ureteral mesenchyme

The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites

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303-313

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10.1016/J.DEVCEL.2008.12.003

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Philippe Soriano

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19217431

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connective tissue

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