SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β. - Wikidata - awgldk - TriplyDB

SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.

SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.

http://www.wikidata.org/entity/Q34946464

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Microglial Priming and Alzheimer's Disease: A Possible Role for (Early) Immune Challenges and Epigenetics?Age-Associated Weight Gain, Leptin, and SIRT1: A Possible Role for Hypothalamic SIRT1 in the Prevention of Weight Gain and Aging through Modulation of Leptin Sensitivity Microglial cell dysregulation in brain aging and neurodegeneration Microglia communication: Parallels between aging and Alzheimer's disease Dietary Phytochemicals in Neuroimmunoaging: A New Therapeutic Possibility for Humans?Immunomodulators as Therapeutic Agents in Mitigating the Progression of Parkinson's Disease Epigenetics and therapeutic targets mediating neuroprotection Glial contributions to neurodegeneration in tauopathies.SIRT1 in the brain-connections with aging-associated disorders and lifespan Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration Deciphering transcriptome profiles of peripheral blood mononuclear cells in response to PRRSV vaccination in pigs.Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1β Axis in Microglia.Recent Developments in Understanding Brain Aging: Implications for Alzheimer's Disease and Vascular Cognitive Impairment.Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia Promoter-Specific Hypomethylation Correlates with IL-1β Overexpression in Tuberous Sclerosis Complex (TSC).The Role of Sirt1 in Epileptogenesis Tert-buthylhydroquinone pre-conditioning exerts dual effects in old female rats exposed to 3-nitropropionic acid.Resveratrol Attenuates Neurodegeneration and Improves Neurological Outcomes after Intracerebral Hemorrhage in Mice.Neuro-immune dysfunction during brain aging: new insights in microglial cell regulation Chromatin Changes Associated with Neuronal Maintenance and Their Pharmacological Application.Mechanisms of microglial activation in models of inflammation and hypoxia: Implications for chronic intermittent hypoxia.PDE4B as a microglia target to reduce neuroinflammation.Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration.Reverse Expression of Aging-Associated Molecules through Transfection of miRNAs to Aged Mice.Age-Dependent Changes in the Activation and Regulation of Microglia.NAD and the aging process: Role in life, death and everything in between.DNA Methylation Profiles of Selected Pro-Inflammatory Cytokines in Alzheimer Disease.Aging leads to altered microglial function that reduces brain resiliency increasing vulnerability to neurodegenerative diseases.The brain, sirtuins, and ageing.Aging and peripheral lipopolysaccharide can modulate epigenetic regulators and decrease IL-1β promoter DNA methylation in microglia.Sustained Effects of Neonatal Systemic Lipopolysaccharide on IL-1β and Nrf2 in Adult Rat Substantia Nigra Are Partly Normalized by a Spirulina-Enriched Diet.Quantitative-profiling of neurotransmitter abnormalities in the disease progression of experimental diabetic encephalopathy rat.Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling.Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1.SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models.Alpha-Lipoic Acid Downregulates IL-1β and IL-6 by DNA Hypermethylation in SK-N-BE Neuroblastoma Cells.Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain.Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance.Spirulina diet to lactating mothers protects the antioxidant system and reduces inflammation in post-natal brain after systemic inflammation.Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer's disease via SIRT1/NF-κB pathway.

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P2860

SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.

http://www.wikidata.org/entity/Q34946464

description

2015 nî lūn-bûn

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2015 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2015 թվականի հունվարին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年论文

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name

SIRT1 deficiency in microglia ...... pigenetic regulation of IL-1β.

@ast

SIRT1 deficiency in microglia ...... pigenetic regulation of IL-1β.

@en

SIRT1 deficiency in microglia ...... pigenetic regulation of IL-1β.

@nl

type

label

SIRT1 deficiency in microglia ...... pigenetic regulation of IL-1β.

@ast

SIRT1 deficiency in microglia ...... pigenetic regulation of IL-1β.

@en

SIRT1 deficiency in microglia ...... pigenetic regulation of IL-1β.

@nl

prefLabel

SIRT1 deficiency in microglia ...... pigenetic regulation of IL-1β.

@ast

SIRT1 deficiency in microglia ...... pigenetic regulation of IL-1β.

@en

SIRT1 deficiency in microglia ...... pigenetic regulation of IL-1β.

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JNEUROSCI.2939-14.2015

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Journal of Neuroscience

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SIRT1 deficiency in microglia ...... epigenetic regulation of IL-1β

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P2093

Fuying Gao

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Giovanni Coppola

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Grietje Krabbe

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Iris Lo

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Li Gan

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Nino Devidze

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Peter Dongmin Sohn

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Sakura Minami

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Seo-Hyun Cho

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Thi A Nguyen

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P2860

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.

SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities

Protective effects and mechanisms of sirtuins in the nervous system

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

Identification of a unique TGF-β-dependent molecular and functional signature in microglia

Functions of DNA methylation: islands, start sites, gene bodies and beyond

Sirtuins in mammals: insights into their biological function

A general framework for weighted gene co-expression network analysis

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