Functional redundancy between human SHOX and mouse Shox2 genes in the regulation of sinoatrial node formation and pacemaking function. - Wikidata - awgldk - TriplyDB

Functional redundancy between human SHOX and mouse Shox2 genes in the regulation of sinoatrial node formation and pacemaking function.

Functional redundancy between human SHOX and mouse Shox2 genes in the regulation of sinoatrial node formation and pacemaking function.

http://www.wikidata.org/entity/Q34947910

about

Identification of novel SHOX target genes in the developing limb using a transgenic mouse model A regulatory path associated with X-linked intellectual disability and epilepsy links KDM5C to the polyalanine expansions in ARX Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb.Tbx4 interacts with the short stature homeobox gene Shox2 in limb development.The short stature homeobox 2 (Shox2)-bone morphogenetic protein (BMP) pathway regulates dorsal mesenchymal protrusion development and its temporary function as a pacemaker during cardiogenesis.Phosphorylation of Shox2 is required for its function to control sinoatrial node formation.Potential effects of intrinsic heart pacemaker cell mechanisms on dysrhythmic cardiac action potential firing Transcription factor ISL1 is essential for pacemaker development and function.Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation.A Track Record on SHOX: From Basic Research to Complex Models and Therapy Expressing human SHOX in Shox2SHOX KI/KI mice leads to congenital osteoarthritis‑like disease of the temporomandibular joint in postnatal mice.NPPB and ACAN, two novel SHOX2 transcription targets implicated in skeletal development.When orthologs diverge between human and mouse.Development of the cardiac pacemaker Elevated SHOX2 expression is associated with tumor recurrence of hepatocellular carcinoma.Concise Review: Criteria for Chamber-Specific Categorization of Human Cardiac Myocytes Derived from Pluripotent Stem Cells.Islet1 is a direct transcriptional target of the homeodomain transcription factor Shox2 and rescues the Shox2-mediated bradycardia.Overexpression of Shox2 leads to congenital dysplasia of the temporomandibular joint in mice.Replacing Shox2 with human SHOX leads to congenital disc degeneration of the temporomandibular joint in mice.Significant variations in alternative splicing patterns and expression profiles between human-mouse orthologs in early embryos.On the Evolution of the Cardiac Pacemaker.The role of Shox2 in SAN development and function.A loss-of-function mutation underlying familial atrial fibrillation

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Functional redundancy between human SHOX and mouse Shox2 genes in the regulation of sinoatrial node formation and pacemaking function.

http://www.wikidata.org/entity/Q34947910

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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JBC.M111.234252

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Journal of Biological Chemistry

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Functional redundancy between ...... mation and pacemaking function

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Chao-Hui Chen

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Hongbing Liu

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Ivana Sheu

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Minkui Lin

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Xuefeng Hu

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Yanding Zhang

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YiPing Chen

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Zhen Jiao

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P2860

SHOT, a SHOX-related homeobox gene, is implicated in craniofacial, brain, heart, and limb development

SHOX mutations in dyschondrosteosis (Leri-Weill syndrome)

PHOG, a candidate gene for involvement in the short stature of Turner syndrome

Cloning and characterization of four murine homeobox genes

rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

The Leri-Weill and Turner syndrome homeobox gene SHOX encodes a cell-type specific transcriptional activator

Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome

Mutation and deletion of the pseudoautosomal gene SHOX cause Leri-Weill dyschondrosteosis

Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21

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17029-17038

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10.1074/JBC.M111.234252

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19

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286

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Ramón A Espinoza-Lewis

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2011-03-28T00:00:00Z

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21454626

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