The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold.

The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold.

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http://www.wikidata.org/entity/Q34975026
Novel class of medications, orexin receptor antagonists, in the treatment of insomnia - critical appraisal of suvorexantOrexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomniaInferring cortical function in the mouse visual system through large-scale systems neuroscienceInhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in MonkeysDifferential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulatorsQuantitative proteomics in laser capture microdissected sleep nuclei from rat brain.Hypothalamic orexin's role in exacerbated cutaneous vasodilation responses to an anxiogenic stimulus in a surgical menopause modelOn-the-Road Driving Performance the Morning after Bedtime Use of Suvorexant 20 and 40 mg: A Study in Non-Elderly Healthy VolunteersDual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators.Sleep-Wake Disturbances After Traumatic Brain Injury: Synthesis of Human and Animal Studies.Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain.Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist.Distinct effects of IPSU and suvorexant on mouse sleep architecture.OREXIN 1 AND 2 RECEPTOR INVOLVEMENT IN CO2 -INDUCED PANIC-ASSOCIATED BEHAVIOR AND AUTONOMIC RESPONSES.Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach.Pharmacological evaluation of orexin receptor antagonists in preclinical animal models of pain.
P2860

The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold.

Item
http://www.wikidata.org/entity/Q34975026
description
2013 nî lūn-bûn
@nan
2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
The duration of sleep promotin ...... receptor occupancy threshold.
@ast
The duration of sleep promotin ...... receptor occupancy threshold.
@en
The duration of sleep promotin ...... receptor occupancy threshold.
@nl
type
label
The duration of sleep promotin ...... receptor occupancy threshold.
@ast
The duration of sleep promotin ...... receptor occupancy threshold.
@en
The duration of sleep promotin ...... receptor occupancy threshold.
@nl
prefLabel
The duration of sleep promotin ...... receptor occupancy threshold.
@ast
The duration of sleep promotin ...... receptor occupancy threshold.
@en
The duration of sleep promotin ...... receptor occupancy threshold.
@nl
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P478
P50
P577
P5875
P6179
P698
P932
P356
P1433
P1476
The duration of sleep promotin ...... receptor occupancy threshold.
@en
P2093
P2860
P2888
P304
P31
P356
P478
P50
P577
P5875
P6179
P698
P932