Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription
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Condor-COPASI: high-throughput computing for biochemical networksTowards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesTranscription dynamics in plant immunityTNF biology, pathogenic mechanisms and emerging therapeutic strategiesThe prolactin gene: a paradigm of tissue-specific gene regulation with complex temporal transcription dynamicsMetabolomics and systems pharmacology: why and how to model the human metabolic network for drug discoveryModeling the intra- and extracellular cytokine signaling pathway under heat stroke in the liverRoles of spatial parameters on the oscillation of nuclear NF-κB: computer simulations of a 3D spherical cellHigh-throughput analysis of NF-κB dynamics in single cells reveals basal nuclear localization of NF-κB and spontaneous activation of oscillationsSignal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states.A spatio-temporal model of Notch signalling in the zebrafish segmentation clock: conditions for synchronised oscillatory dynamicsLessons from mathematically modeling the NF-κB pathway.Quantitative imaging of mammalian transcriptional dynamics: from single cells to whole embryosQuantitative and logic modelling of molecular and gene networksRobustness of circadian clocks to daylight fluctuations: hints from the picoeucaryote Ostreococcus tauriAutomated analysis of NF-κB nuclear translocation kinetics in high-throughput screeningWhat can we learn from global sensitivity analysis of biochemical systems?Accurate encoding and decoding by single cells: amplitude versus frequency modulationInformation transduction capacity of noisy biochemical signaling networksA Bacterial Component to Alzheimer’s-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to DiseaseLipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors.Genome-wide predictors of NF-κB recruitment and transcriptional activitySignalling ballet in space and timePituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood.Rate of environmental change determines stress response specificity.Circuit-level input integration in bacterial gene regulation.Signal-dependent dynamics of transcription factor translocation controls gene expression.Promoter decoding of transcription factor dynamics involves a trade-off between noise and control of gene expressionNF-κB signalling and cell fate decisions in response to a short pulse of tumour necrosis factor.Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information.Complex dynamics of transcription regulation.A model for the epigenetic switch linking inflammation to cell transformation: deterministic and stochastic approachesIdentification of new IκBα complexes by an iterative experimental and mathematical modeling approach.High-throughput and single-cell imaging of NF-kappaB oscillations using monoclonal cell lines.Regulation of NF-kappaB inhibitor IkappaBalpha and viral replication by a KSHV microRNATrade-offs and noise tolerance in signal detection by genetic circuits.From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine.IL-17A mediates a selective gene expression profile in asthmatic human airway smooth muscle cells.Interactions among oscillatory pathways in NF-kappa B signaling.
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P2860
Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Pulsatile stimulation determin ...... kappaB-dependent transcription
@ast
Pulsatile stimulation determin ...... kappaB-dependent transcription
@en
Pulsatile stimulation determin ...... kappaB-dependent transcription
@nl
type
label
Pulsatile stimulation determin ...... kappaB-dependent transcription
@ast
Pulsatile stimulation determin ...... kappaB-dependent transcription
@en
Pulsatile stimulation determin ...... kappaB-dependent transcription
@nl
prefLabel
Pulsatile stimulation determin ...... kappaB-dependent transcription
@ast
Pulsatile stimulation determin ...... kappaB-dependent transcription
@en
Pulsatile stimulation determin ...... kappaB-dependent transcription
@nl
P2093
P2860
P50
P356
P1433
P1476
Pulsatile stimulation determin ...... kappaB-dependent transcription
@en
P2093
Caroline A Horton
Claire V Harper
David S Broomhead
John F Unitt
Kate Sillitoe
Louise Ashall
Sheila Ryan
Violaine Sée
P2860
P304
P356
10.1126/SCIENCE.1164860
P407
P577
2009-04-01T00:00:00Z