Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain.
about
New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8.Targeting protein-protein interactions to rescue Δf508-cftr: a novel corrector approach to treat cystic fibrosis.Marked repression of CFTR mRNA in the transgenic Cftr(tm1kth) mouse model.PharmGKB summary: very important pharmacogene information for CFTRMolecular modelling and molecular dynamics of CFTR.Hallmarks of therapeutic management of the cystic fibrosis functional landscape.Unravelling druggable signalling networks that control F508del-CFTR proteostasisRestoration of NBD1 thermal stability is necessary and sufficient to correct ∆F508 CFTR folding and assemblyBinding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategyThe safety dance: biophysics of membrane protein folding and misfolding in a cellular contextPhenylhydrazones as Correctors of a Mutant Cystic Fibrosis Transmembrane Conductance Regulator.Performance of machine-learning scoring functions in structure-based virtual screening.Biophysical Approaches Facilitate Computational Drug Discovery for ATP-Binding Cassette Proteins.Finding new drugs to enhance anion secretion in cystic fibrosis: Toward suitable systems for better drug screening. Report on the pre-conference meeting to the 12th ECFS Basic Science Conference, Albufeira, 25-28 March 2015.rAAV-CFTRΔR Rescues the Cystic Fibrosis Phenotype in Human Intestinal Organoids and Cystic Fibrosis Mice.CFTR pharmacology.An unexpected effect of TNF-α on F508del-CFTR maturation and function.Speeding Up the Identification of Cystic Fibrosis Transmembrane Conductance Regulator-Targeted Drugs: An Approach Based on Bioinformatics Strategies and Surface Plasmon Resonance.Cis variants identified in F508del complex alleles modulate CFTR channel rescue by small molecules.Genetic deletion of keratin 8 corrects the altered bone formation and osteopenia in a mouse model of cystic fibrosis.Molecular basis of cystic fibrosis: from bench to bedside
P2860
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P2860
Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain.
description
2013 nî lūn-bûn
@nan
2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Discovery of novel potent ΔF50 ...... the nucleotide binding domain.
@ast
Discovery of novel potent ΔF50 ...... the nucleotide binding domain.
@en
Discovery of novel potent ΔF50 ...... the nucleotide binding domain.
@nl
type
label
Discovery of novel potent ΔF50 ...... the nucleotide binding domain.
@ast
Discovery of novel potent ΔF50 ...... the nucleotide binding domain.
@en
Discovery of novel potent ΔF50 ...... the nucleotide binding domain.
@nl
prefLabel
Discovery of novel potent ΔF50 ...... the nucleotide binding domain.
@ast
Discovery of novel potent ΔF50 ...... the nucleotide binding domain.
@en
Discovery of novel potent ΔF50 ...... the nucleotide binding domain.
@nl
P2093
P2860
P356
P1476
Discovery of novel potent ΔF50 ...... the nucleotide binding domain.
@en
P2093
Aleksander Edelman
Anna Kupniewska
Ariel Roldan
Caroline Norez
Danielle Tondelier
Emilie L Saussereau
Frédéric Becq
Gergely L Lukacs
Grazyna Faure
Grzegorz Wieczorek
P2860
P304
P356
10.1002/EMMM.201302699
P577
2013-08-27T00:00:00Z