Identifying and characterizing binding sites and assessing druggability.
about
Druggability Assessment of Allosteric Proteins by Dynamics Simulations in the Presence of Probe MoleculesInsights into the molecular mechanism of allostery in Hsp70s.Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactionsTherapeutic target-site variability in α1-antitrypsin characterized at high resolutionParalog-selective Hsp90 inhibitors define tumor-specific regulation of HER2Functional analysis of Hsp70 inhibitorsStructure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure–Activity Analysis of Inhibitor AnalogsSelectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitorsObserved bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.Small Molecule-Photoactive Yellow Protein Labeling Technology in Live Cell ImagingIdentification of potential small molecule binding pockets on Rho family GTPasesIn silico assessment of potential druggable pockets on the surface of α1-antitrypsin conformersExpanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatinStructural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congenersStructure-based druggability assessment of the mammalian structural proteome with inclusion of light protein flexibilityTransforming growth factor β signaling overcomes dasatinib resistance in lung cancerAdverse drug reaction prediction using scores produced by large-scale drug-protein target docking on high-performance computing machinesApaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicityTo Hit or Not to Hit, That Is the Question - Genome-wide Structure-Based Druggability Predictions for Pseudomonas aeruginosa ProteinspMD-Membrane: A Method for Ligand Binding Site Identification in Membrane-Bound ProteinsMixed Inhibition of cPEPCK by Genistein, Using an Extended Binding Site Located Adjacent to Its Catalytic CleftPredicting Ligand Binding Sites on Protein Surfaces by 3-Dimensional Probability Density Distributions of Interacting AtomsIncreasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule TherapeuticsThe oleocanthal-based homovanillyl sinapate as a novel c-Met inhibitorIdentification of novel natural compound inhibitors for human complement component 5a receptor by homology modeling and virtual screeningEmerging Computational Methods for the Rational Discovery of Allosteric Drugs.TuberQ: a Mycobacterium tuberculosis protein druggability databaseFlavonoids as multi-target inhibitors for proteins associated with Ebola virus: in-silico discovery using virtual screening and molecular docking studies.PockDrug-Server: a new web server for predicting pocket druggability on holo and apo proteins.Fractal Dimensions of Macromolecular Structures.Flavonoids as Multi-target Inhibitors for Proteins Associated with Ebola Virus: In Silico Discovery Using Virtual Screening and Molecular Docking Studies.AutoSite: an automated approach for pseudo-ligands prediction-from ligand-binding sites identification to predicting key ligand atoms.Computational methods in drug discovery.Rapid analysis of pharmacology for infectious diseasesInvestigating the Importance of the Pocket-estimation Method in Pocket-based Approaches: An Illustration Using Pocket-ligand Classification.Identifying ligand binding sites and poses using GPU-accelerated Hamiltonian replica exchange molecular dynamics.Protein pockets: inventory, shape, and comparisonSmall molecule correctors of F508del-CFTR discovered by structure-based virtual screeningUsing RosettaLigand for small molecule docking into comparative models.
P2860
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P2860
Identifying and characterizing binding sites and assessing druggability.
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Identifying and characterizing binding sites and assessing druggability.
@ast
Identifying and characterizing binding sites and assessing druggability.
@en
Identifying and characterizing binding sites and assessing druggability.
@nl
type
label
Identifying and characterizing binding sites and assessing druggability.
@ast
Identifying and characterizing binding sites and assessing druggability.
@en
Identifying and characterizing binding sites and assessing druggability.
@nl
prefLabel
Identifying and characterizing binding sites and assessing druggability.
@ast
Identifying and characterizing binding sites and assessing druggability.
@en
Identifying and characterizing binding sites and assessing druggability.
@nl
P356
P1476
Identifying and characterizing binding sites and assessing druggability.
@en
P2093
Thomas A Halgren
P304
P356
10.1021/CI800324M
P577
2009-02-01T00:00:00Z