Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages. - Wikidata - awgldk - TriplyDB

Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages.

Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages.

http://www.wikidata.org/entity/Q34985249

about

Secondary structure prediction and in vitro accessibility of mRNA as tools in the selection of target sites for ribozymes New NTP analogs: the synthesis of 4'-thioUTP and 4'-thioCTP and their utility for SELEX Redesigned and chemically-modified hammerhead ribozymes with improved activity and serum stability Down-regulation of plasminogen activator inhibitor 1 expression promotes myocardial neovascularization by bone marrow progenitors Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells Protection of HIV neutralizing aptamers against rectal and vaginal nucleases: implications for RNA-based therapeutics.Characterization of several kinds of dimer minizyme: simultaneous cleavage at two sites in HIV-1 tat mRNA by dimer minizymes.Selection of the best target site for ribozyme-mediated cleavage within a fusion gene for adenovirus E1A-associated 300 kDa protein (p300) and luciferase.Effects of helical structures formed by the binding arms of DNAzymes and their substrates on catalytic activity Discrimination of a single base change in a ribozyme using the gene for dihydrofolate reductase as a selective marker in Escherichia coli.Use of ribozymes and antisense oligodeoxynucleotides to investigate mechanisms of drug resistance Importance of independence in ribozyme reactions: kinetic behavior of trimmed and of simply connected multiple ribozymes with potential activity against human immunodeficiency virus.Detection of undegraded oligonucleotides in vivo by fluorescence resonance energy transfer. Nuclease activities in living sea urchin eggs.Explanation by the double-metal-ion mechanism of catalysis for the differential metal ion effects on the cleavage rates of 5'-oxy and 5'-thio substrates by a hammerhead ribozyme.Simultaneous detection of cell-secreted TNF-α and IFN-γ using micropatterned aptamer-modified electrodes.A multifunctional expression vector for an anti-HIV-1 ribozyme that produces a 5'- and 3'-trimmed trans-acting ribozyme, targeted against HIV-1 RNA, and cis-acting ribozymes that are designed to bind to and thereby sequester trans-activator proteins Ribozyme-mediated cleavage of the MDR-1 transcript restores chemosensitivity in previously resistant cancer cells.Ribonuclease H attack of leukaemic fused transcripts AML1-MTG8 (ETO) by DNA/RNA chimeric hammerhead ribozymes.Dependence on Mg2+ ions of the activities of dimeric hammerhead minizymes.Nanoparticles and DNA - a powerful and growing functional combination in bionanotechnology.Novel targeted liposomes deliver sirna to hepatocellular carcinoma cells in vitro.Specific Increase of Protein Levels by Enhancing Translation Using Antisense Oligonucleotides Targeting Upstream Open Frames.The contribution of 2'-hydroxyls to the cleavage activity of the Neurospora VS ribozyme.In vitro selection and characterization of a highly efficient Zn(II)-dependent RNA-cleaving deoxyribozyme.Synthesis and physical and physiological properties of 4'-thioRNA: application to post-modification of RNA aptamer toward NF-kappaB In vitro activity of minimised hammerhead ribozymes A comparison of the in vitro activity of DNA-armed and all-RNA hammerhead ribozymes.An oligodeoxyribonucleotide that supports catalytic activity in the hammerhead ribozyme domain Synthesis of 2'-modified nucleotides and their incorporation into hammerhead ribozymes.Probing the hammerhead ribozyme structure with ribonucleases.Enhancement of the cleavage rates of DNA-armed hammerhead ribozymes by various divalent metal ions.The influence of imperfectly paired helices I and III on the catalytic activity of hammerhead ribozymes.Downregulation of bcl-2 expression in lymphoma cells by bcl-2 ARE-targeted modified, synthetic ribozyme.Ribozyme-mediated suppression of the G protein gamma7 subunit suggests a role in hormone regulation of adenylylcyclase activity.Synthesis and characterization of 2'-modified-4'-thioRNA: a comprehensive comparison of nuclease stability.Hammerhead ribozyme kinetics.Inhibition of growth of human gingival fibroblasts by chimeric DNA-RNA hammerhead ribozyme targeting transforming growth factor-beta 1.DNA oligonucleotides containing stereodefined phosphorothioate linkages in selected positions.

P2860

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P2860

Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages.

http://www.wikidata.org/entity/Q34985249

description

1993 nî lūn-bûn

@nan

1993 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

1993 թվականի հունիսին հրատարակված գիտական հոդված

@hy

1993年の論文

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1993年論文

@yue

1993年論文

@zh-hant

1993年論文

@zh-hk

1993年論文

@zh-mo

1993年論文

@zh-tw

1993年论文

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name

Nuclease-resistant chimeric ri ...... and phosphorothioate linkages.

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Nuclease-resistant chimeric ri ...... and phosphorothioate linkages.

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Nuclease-resistant chimeric ri ...... and phosphorothioate linkages.

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type

label

Nuclease-resistant chimeric ri ...... and phosphorothioate linkages.

@ast

Nuclease-resistant chimeric ri ...... and phosphorothioate linkages.

@en

Nuclease-resistant chimeric ri ...... and phosphorothioate linkages.

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prefLabel

Nuclease-resistant chimeric ri ...... and phosphorothioate linkages.

@ast

Nuclease-resistant chimeric ri ...... and phosphorothioate linkages.

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Nuclease-resistant chimeric ri ...... and phosphorothioate linkages.

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P1433

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P932

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P1433

Nucleic Acids Research

P1476

Nuclease-resistant chimeric ri ...... and phosphorothioate linkages.

@en

P2093

Nishikawa F

http://www.w3.org/2001/XMLSchema#string

Nishikawa S

http://www.w3.org/2001/XMLSchema#string

Shimayama T

http://www.w3.org/2001/XMLSchema#string

Taira K

http://www.w3.org/2001/XMLSchema#string

P2860

Autolytic processing of dimeric plant virus satellite RNA

Self-cleaving transcripts of satellite DNA from the newt

Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites

Metal ion catalysis in the Tetrahymena ribozyme reaction

Mutations in a nonconserved sequence of the Tetrahymena ribozyme increase activity and specificity.

RNA as an enzyme.

Novel route to oligo(deoxyribonucleoside phosphorothioates). Stereocontrolled synthesis of P-chiral oligo(deoxyribonucleoside phosphorothioates).

Numbering system for the hammerhead.

Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo.

Function of specific 2'-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2' modifications

P304

2605-2611

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P31

scholarly article

P356

10.1093/NAR/21.11.2605

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P407

P433

11

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P478

21

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P577

1993-06-01T00:00:00Z

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P5875

14867758

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P698

8332458

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P921

P932

309588

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