Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice - Wikidata - awgldk - TriplyDB

Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice

Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice

http://www.wikidata.org/entity/Q34990925

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A periodic table for cancer Adhesion in mammary development: novel roles for E-cadherin in individual and collective cell migration Nuclear Kaiso expression is associated with high grade and triple-negative invasive breast cancer p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis.Loss of CDH1 and Pten accelerates cellular invasiveness and angiogenesis in the mouse uterus.Lobular breast cancer: molecular basis, mouse and cellular models.Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis.Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance.Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/⁺WAPCre mouse model AEG-1 promotes anoikis resistance and orientation chemotaxis in hepatocellular carcinoma cells.Choosing a mouse model: experimental biology in context--the utility and limitations of mouse models of breast cancer.Nuclear p120-catenin regulates the anoikis resistance of mouse lobular breast cancer cells through Kaiso-dependent Wnt11 expression Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation.Loss of Cdh1 and Trp53 in the uterus induces chronic inflammation with modification of tumor microenvironment Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium.Loss of plakoglobin promotes decreased cell-cell contact, increased invasion, and breast cancer cell dissemination in vivo Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer Proteomics of genetically engineered mouse mammary tumors identifies fatty acid metabolism members as potential predictive markers for cisplatin resistance.Defined lipid analogues induce transient channels to facilitate drug-membrane traversal and circumvent cancer therapy resistance Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland.PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma.p120-Catenin Is Critical for the Development of Invasive Lobular Carcinoma in Mice Lobular breast cancer: pathology, biology, and options for clinical intervention.Beyond E-cadherin: roles of other cadherin superfamily members in cancer.E-cadherin's role in development, tissue homeostasis and disease: Insights from mouse models: Tissue-specific inactivation of the adhesion protein E-cadherin in mice reveals its functions in health and disease.The relevance of EMT in breast cancer metastasis: Correlation or causality?Overview of Genetically Engineered Mouse Models of Breast Cancer Used in Translational Biology and Drug Development.Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer.IPH-926 lobular breast cancer cells harbor a p53 mutant with temperature-sensitive functional activity and allow for profiling of p53-responsive genes.Acquisition of anoikis resistance through CD147 upregulation: A new mechanism underlying metastasis of hepatocellular carcinoma cells.Restraining FOXO3-dependent transcriptional BMF activation underpins tumour growth and metastasis of E-cadherin-negative breast cancer Intraductal cisplatin treatment in a BRCA-associated breast cancer mouse model attenuates tumor development but leads to systemic tumors in aged female mice Break Breast Cancer Addiction by CRISPR/Cas9 Genome Editing.Lobular carcinoma in situ and invasive lobular breast cancer are characterized by enhanced expression of transcription factor AP-2β.Correlation between E-cadherin and p120 expression in invasive ductal breast cancer with a lobular component and MRI findings.Using the GEMM-ESC strategy to study gene function in mouse models.Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma.Pulling cells out of tumours.Aging Mouse Models Reveal Complex Tumor-Microenvironment Interactions in Cancer Progression.IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma.

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Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice

http://www.wikidata.org/entity/Q34990925

description

2011 nî lūn-bûn

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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Mammary-specific inactivation ...... sive lobular carcinoma in mice

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Mammary-specific inactivation ...... sive lobular carcinoma in mice

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Mammary-specific inactivation ...... sive lobular carcinoma in mice

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Mammary-specific inactivation ...... sive lobular carcinoma in mice

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Mammary-specific inactivation ...... sive lobular carcinoma in mice

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Mammary-specific inactivation ...... sive lobular carcinoma in mice

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Mammary-specific inactivation ...... sive lobular carcinoma in mice

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Mammary-specific inactivation ...... sive lobular carcinoma in mice

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Mammary-specific inactivation ...... sive lobular carcinoma in mice

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Disease Models & Mechanisms

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Mammary-specific inactivation ...... sive lobular carcinoma in mice

@en

P2093

Eline van der Burg

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Elly Mesman

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Jelle Wesseling

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Jos Jonkers

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Marten Hornsveld

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Patrick W B Derksen

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Paul Krimpenfort

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Tanya M Braumuller

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P2860

Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome

The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton

E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers

Matrix crosslinking forces tumor progression by enhancing integrin signaling

The diagnosis and management of pre-invasive breast disease: pathology of atypical lobular hyperplasia and lobular carcinoma in situ

Generalized lacZ expression with the ROSA26 Cre reporter strain

Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis

The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells

MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer

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347-358

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10.1242/DMM.006395

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3

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4

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21282721

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3097456

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