A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity. - Wikidata - awgldk - TriplyDB

A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity.

A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity.

http://www.wikidata.org/entity/Q34996919

about

The ubiquitin system: a critical regulator of innate immunity and pathogen-host interactions Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance?Linear ubiquitination in immunity The intersection of cell death and inflammasome activation NF-κB Pathway in Autoinflammatory Diseases: Dysregulation of Protein Modifications by Ubiquitin Defines a New Category of Autoinflammatory Diseases.Hypomorphic A20 expression confers susceptibility to psoriasis.The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3 Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling Anti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens.A20 overexpression alleviates pristine-induced lupus nephritis by inhibiting the NF-κB and NLRP3 inflammasome activation in macrophages of mice.Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease Novel heterozygous C243Y A20/TNFAIP3 gene mutation is responsible for chronic inflammation in autosomal-dominant Behçet's disease Posttranscriptional control of NLRP3 inflammasome activation in colonic macrophages.Connectivity mapping (ssCMap) to predict A20-inducing drugs and their antiinflammatory action in cystic fibrosis.The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3.Post-translational regulation of inflammasomes.Caspase-8: not so silently deadly.The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination.Geoepidemiology and Immunologic Features of Autoinflammatory Diseases: a Comprehensive Review.Regulation of inflammasomes by ubiquitination.Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.Autoinflammatory diseases: update on classification diagnosis and management.Lessons from characterization and treatment of the autoinflammatory syndromes.Mechanisms of RIPK3-induced inflammation.The Inflammatory Signal Adaptor RIPK3: Functions Beyond Necroptosis.30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology.Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling.CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so different.Inflammasomes and intestinal inflammation.The many ways tissue phagocytes respond to dying cells.Posttranslational Modification as a Critical Determinant of Cytoplasmic Innate Immune Recognition.Interleukin 17 Family Cytokines: Signaling Mechanisms, Biological Activities, and Therapeutic Implications.Genomics, Biology, and Human Illness: Advances in the Monogenic Autoinflammatory Diseases.The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation.A20 reduces lipid storage and inflammation in hypertrophic adipocytes via p38 and Akt signaling.Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals.The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1β Secretion by Inflammasomes.K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo.

P2860

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P2860

A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity.

http://www.wikidata.org/entity/Q34996919

description

2015 nî lūn-bûn

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2015 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2015 թվականի հունվարին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

A20 restricts ubiquitination o ...... s NLRP3 inflammasome activity.

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A20 restricts ubiquitination o ...... s NLRP3 inflammasome activity.

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A20 restricts ubiquitination o ...... s NLRP3 inflammasome activity.

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type

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A20 restricts ubiquitination o ...... s NLRP3 inflammasome activity.

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A20 restricts ubiquitination o ...... s NLRP3 inflammasome activity.

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A20 restricts ubiquitination o ...... s NLRP3 inflammasome activity.

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A20 restricts ubiquitination o ...... s NLRP3 inflammasome activity.

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A20 restricts ubiquitination o ...... s NLRP3 inflammasome activity.

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A20 restricts ubiquitination o ...... s NLRP3 inflammasome activity.

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J.IMMUNI.2014.12.031

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P1476

A20 restricts ubiquitination o ...... s NLRP3 inflammasome activity.

@en

P2093

Averil Ma

http://www.w3.org/2001/XMLSchema#string

Bao H Duong

http://www.w3.org/2001/XMLSchema#string

Barbara A Malynn

http://www.w3.org/2001/XMLSchema#string

Juan A Oses-Prieto

http://www.w3.org/2001/XMLSchema#string

Michio Onizawa

http://www.w3.org/2001/XMLSchema#string

Rommel Advincula

http://www.w3.org/2001/XMLSchema#string

P2860

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module

Direct activation of protein kinases by unanchored polyubiquitin chains

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55-67

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scholarly article

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10.1016/J.IMMUNI.2014.12.031

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1

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42

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Alma L Burlingame

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2015-01-01T00:00:00Z

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25607459

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protein ubiquitination

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4302274

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