Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.

Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.

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http://www.wikidata.org/entity/Q35000243

Q35000243

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The Role of MicroRNAs as Predictors of Response to Tamoxifen Treatment in Breast Cancer Patients Targeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis and immunotherapy Pictilisib for oestrogen receptor-positive, aromatase inhibitor-resistant, advanced or metastatic breast cancer (FERGI): a randomised, double-blind, placebo-controlled, phase 2 trial.Targeting PTEN-defined breast cancers with a one-two punch.PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer.The changing role of ER in endocrine resistance.Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression.FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer.DUSP1 promoter methylation in peripheral blood leukocyte is associated with triple-negative breast cancer risk.JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer.Deubiquitinases and the new therapeutic opportunities offered to cancer.Challenges in the management of advanced, ER-positive, HER2-negative breast cancer.De-escalation of treatment in HER2-positive breast cancer: Determinants of response and mechanisms of resistance.Thy-1+ Cancer-associated Fibroblasts Adversely Impact Lung Cancer Prognosis.PTEN expression is upregulated by a RNA-binding protein RBM38 via enhancing its mRNA stability in breast cancer.Targeting protein quality control pathways in breast cancer.Integrated molecular analysis of Tamoxifen-resistant invasive lobular breast cancer cells identifies MAPK and GRM/mGluR signaling as therapeutic vulnerabilities.Protein Kinase Targets in Breast Cancer.miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer.Low PTEN levels and PIK3CA mutations predict resistance to neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2 over-expressing breast cancer.The impact of PI3K inhibitors on breast cancer cell and its tumor microenvironment.Current Landscape of Targeted Therapies for Hormone-Receptor Positive, HER2 Negative Metastatic Breast Cancer

P2860

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P2860

Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.

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http://www.wikidata.org/entity/Q35000243

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2014 nî lūn-bûn

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2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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