Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib. - Wikidata - awgldk - TriplyDB

Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib.

Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib.

http://www.wikidata.org/entity/Q35002433

about

Mechanism-based inactivation of CYP450 enzymes: a case study of lapatinib Lapatinib antagonizes multidrug resistance-associated protein 1-mediated multidrug resistance by inhibiting its transport function.Studies on the role of metabolic activation in tyrosine kinase inhibitor-dependent hepatotoxicity: induction of CYP3A4 enhances the cytotoxicity of lapatinib in HepaRG cells Genetic characterization to improve interpretation and clinical management of hepatotoxicity caused by tyrosine kinase inhibitors.Formation of reactive metabolites and management of tyrosine kinase inhibitor-induced hepatotoxicity: a literature review.The contributions of Sidney D. Nelson to drug metabolism research.Synergistic disruption of ERα/HER2 crosstalk by endoxifen and lapatinib in breast cancer cells.Cytochrome P450 3A4 and CYP3A5-Catalyzed Bioactivation of Lapatinib Drug-drug interaction potential of marketed oncology drugs: in vitro assessment of time-dependent cytochrome P450 inhibition, reactive metabolite formation and drug-drug interaction prediction.Analysis of Mechanism-Based Inhibition of CYP 3A4 by a Series of Fluoroquinolone Antibacterial Agents.Lapatinib-associated mucocutaneous toxicities are clinical predictors of improved progression-free survival in patients with human epidermal growth factor receptor (HER2)-positive advanced breast cancer.Role of Cytochrome P450 Enzymes in the Metabolic Activation of Tyrosine Kinase Inhibitors

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P2860

Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib.

http://www.wikidata.org/entity/Q35002433

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib.

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Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib.

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type

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Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib.

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Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib.

@en

prefLabel

Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib.

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Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib.

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Drug Metabolism and Disposition

P1476

Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib.

@en

P2093

Chunsheng Zhao

http://www.w3.org/2001/XMLSchema#string

Eric Chun Yong Chan

http://www.w3.org/2001/XMLSchema#string

Hideo Takakusa

http://www.w3.org/2001/XMLSchema#string

Kelsey L Hanson

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Lee Sun New

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Michelle D Wahlin

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Sidney D Nelson

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P2860

Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid

The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer

Genetic contribution to variable human CYP3A-mediated metabolism

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

Risk assessment for drug-drug interaction caused by metabolism-based inhibition of CYP3A using automated in vitro assay systems and its application in the early drug discovery process

Cytochrome P-455 complex formation in the metabolism of phenylalkylamines--IV. Spectral evidences for metabolic conversion of methamphetamine to N-hydroxyamphetamine

A new anti-liver-kidney microsome antibody (anti-LKM2) in tienilic acid-induced hepatitis

Genetic variability in CYP3A5 and its possible consequences.

Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem.

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug

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1022-1030

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scholarly article

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10.1124/DMD.110.037531

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6

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39

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2011-03-01T00:00:00Z

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21363997

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