A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. - Wikidata - awgldk - TriplyDB

A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway.

A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway.

http://www.wikidata.org/entity/Q35003193

about

The clearance of dying cells: table for two Dual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptide Autophagy and neurodegeneration Protein homeostasis as a therapeutic target for diseases of protein conformation Sorting through the roles of beclin 1 in microglia and neurodegeneration Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach The role of mTOR signaling in Alzheimer disease Triptolide preserves cognitive function and reduces neuropathology in a mouse model of Alzheimer's disease Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?A focused small-molecule screen identifies 14 compounds with distinct effects on Toxoplasma gondii.Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.Important role of autophagy in endothelial cell response to ionizing radiation.Bidirectional regulation of Aβ levels by Presenilin 1.Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice GA binding protein augments autophagy via transcriptional activation of BECN1-PIK3C3 complex genes The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain.Induction of autophagy by a novel small molecule improves aβ pathology and ameliorates cognitive deficits Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease.Cilostazol Upregulates Autophagy via SIRT1 Activation: Reducing Amyloid-β Peptide and APP-CTFβ Levels in Neuronal Cells Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases.The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease.Autophagy and neuronal cell death in neurological disorders Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain.Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.Loss of endophilin-B1 exacerbates Alzheimer's disease pathology Rapamycin, Autophagy, and Alzheimer's Disease Membrane trafficking in neuronal maintenance and degeneration.Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology.Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer's Disease.Application and interpretation of current autophagy inhibitors and activators.Autophagy and polyglutamine diseases.Mammalian target of rapamycin: a valid therapeutic target through the autophagy pathway for Alzheimer's disease?Protein homeostasis, aging and Alzheimer's disease.Degradation of tau protein by autophagy and proteasomal pathways.Novel pharmacological modulators of autophagy and therapeutic prospects.Autophagy modulation for Alzheimer's disease therapy.

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A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway.

http://www.wikidata.org/entity/Q35003193

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

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Victor Bustos

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Yuan Tian

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P2860

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

Extension of chronological life span in yeast by decreased TOR pathway signaling

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex

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3101026

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