A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway.
about
The clearance of dying cells: table for twoDual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptideAutophagy and neurodegenerationProtein homeostasis as a therapeutic target for diseases of protein conformationSorting through the roles of beclin 1 in microglia and neurodegenerationAutophagy in neurodegenerative diseases: from mechanism to therapeutic approachThe role of mTOR signaling in Alzheimer diseaseTriptolide preserves cognitive function and reduces neuropathology in a mouse model of Alzheimer's diseaseAftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?A focused small-molecule screen identifies 14 compounds with distinct effects on Toxoplasma gondii.Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.Important role of autophagy in endothelial cell response to ionizing radiation.Bidirectional regulation of Aβ levels by Presenilin 1.Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic miceGA binding protein augments autophagy via transcriptional activation of BECN1-PIK3C3 complex genesThe adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain.Induction of autophagy by a novel small molecule improves aβ pathology and ameliorates cognitive deficitsRegulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease.Cilostazol Upregulates Autophagy via SIRT1 Activation: Reducing Amyloid-β Peptide and APP-CTFβ Levels in Neuronal CellsCrosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases.The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease.Autophagy and neuronal cell death in neurological disordersSmall-molecule inducers of Aβ-42 peptide production share a common mechanism of actionLatrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain.Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer diseaseLatrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.Loss of endophilin-B1 exacerbates Alzheimer's disease pathologyRapamycin, Autophagy, and Alzheimer's DiseaseMembrane trafficking in neuronal maintenance and degeneration.Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology.Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer's Disease.Application and interpretation of current autophagy inhibitors and activators.Autophagy and polyglutamine diseases.Mammalian target of rapamycin: a valid therapeutic target through the autophagy pathway for Alzheimer's disease?Protein homeostasis, aging and Alzheimer's disease.Degradation of tau protein by autophagy and proteasomal pathways.Novel pharmacological modulators of autophagy and therapeutic prospects.Autophagy modulation for Alzheimer's disease therapy.
P2860
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P2860
A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A small-molecule enhancer of a ...... 5-dependent autophagy pathway.
@ast
A small-molecule enhancer of a ...... 5-dependent autophagy pathway.
@en
type
label
A small-molecule enhancer of a ...... 5-dependent autophagy pathway.
@ast
A small-molecule enhancer of a ...... 5-dependent autophagy pathway.
@en
prefLabel
A small-molecule enhancer of a ...... 5-dependent autophagy pathway.
@ast
A small-molecule enhancer of a ...... 5-dependent autophagy pathway.
@en
P2860
P356
P1433
P1476
A small-molecule enhancer of a ...... 5-dependent autophagy pathway.
@en
P2093
Victor Bustos
P2860
P304
P356
10.1096/FJ.10-175158
P407
P577
2011-03-02T00:00:00Z