Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma. - Wikidata - awgldk - TriplyDB

Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.

Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.

http://www.wikidata.org/entity/Q35004399

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Perforin and granzyme B have separate and distinct roles during atherosclerotic plaque development in apolipoprotein E knockout mice Serpina3n accelerates tissue repair in a diabetic mouse model of delayed wound healing A quarter century of granzymes Granzyme B degrades extracellular matrix and contributes to delayed wound closure in apolipoprotein E knockout mice Endogenous retinoids in the pathogenesis of alopecia areata Granzyme B cleavage of autoantigens in autoimmunity Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes Insights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis Immunotherapeutic targeting of membrane Hsp70-expressing tumors using recombinant human granzyme B Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-β1 Granzyme K activates protease-activated receptor-1 Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.Proteomic profiling of proteases: tools for granzyme degradomics.Innate CD8αα+ lymphocytes enhance anti-CD40 antibody-mediated colitis in mice.Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability.Impairment of Granzyme B-Producing Regulatory B Cells Correlates with Exacerbated Rheumatoid Arthritis.Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.Granzymes in age-related cardiovascular and pulmonary diseases.Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm.Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection.Granzyme-mediated regulation of host defense in the liver in experimental Leishmania donovani infection.Toxoplasma gondii inhibits granzyme B-mediated apoptosis by the inhibition of granzyme B function in host cells Granzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low-dose ultraviolet light irradiation.The induction of neuronal death by up-regulated microglial cathepsin H in LPS-induced neuroinflammation.Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.B cell-derived circulating granzyme B is a feature of acute infectious mononucleosis.Granzyme B- and Fas ligand-mediated cytotoxic function induced by mitogenic CD28 stimulation of human memory CD4+ T cells Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo.Granzyme B-expressing neutrophils correlate with bacterial load in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques.The proteoglycan repertoire of lymphoid cells Epitelial-to-mesenchimal transition and invasion are upmodulated by tumor-expressed granzyme B and inhibited by docosahexaenoic acid in human colorectal cancer cells.miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells.Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer.Plasma granzyme B in ST elevation myocardial infarction versus non-ST elevation acute coronary syndrome: comparisons with IL-18 and fractalkine Intracellular substrate cleavage: a novel dimension in the biochemistry, biology and pathology of matrix metalloproteinases.Controversies in granzyme biology.Blessing or curse? Proteomics in granzyme research.Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity.Extracellular granzyme K mediates endothelial activation through the cleavage of protease-activated receptor-1.

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Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.

http://www.wikidata.org/entity/Q35004399

description

2009 nî lūn-bûn

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2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Intracellular versus extracell ...... isease: challenging the dogma.

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Intracellular versus extracell ...... isease: challenging the dogma.

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Intracellular versus extracell ...... isease: challenging the dogma.

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Intracellular versus extracell ...... isease: challenging the dogma.

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Intracellular versus extracell ...... isease: challenging the dogma.

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LABINVEST.2009.91

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Laboratory Investigation

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Intracellular versus extracell ...... isease: challenging the dogma.

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P2093

David James Granville

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Dawn Michelle Cooper

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Paul Ryan Hiebert

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Wendy Anne Boivin

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P2860

The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells

Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis

The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses

Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

The granzyme B inhibitor SERPINB9 (protease inhibitor 9) circulates in blood and increases on primary cytomegalovirus infection after renal transplantation

The receptor for the cytotoxic ligand TRAIL

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes

Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation

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labinvest.2009.91

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1195-1220

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10.1038/LABINVEST.2009.91

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26828205

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