SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells. - Wikidata - awgldk - TriplyDB

SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells.

SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells.

http://www.wikidata.org/entity/Q35009327

about

Ubiquitin-specific peptidase 22 functions and its involvement in disease Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis USP22 drives colorectal cancer invasion and metastasis via epithelial-mesenchymal transition by activating AP4.Desynchronization of Circadian Clocks in Cancer: A Metabolic and Epigenetic Connection.E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.Sirtuin-dependent clock control: new advances in metabolism, aging and cancer CD150(-) Side Population Defines Leukemia Stem Cells in a BALB/c Mouse Model of CML and Is Depleted by Genetic Loss of SIRT1 Circadian clocks, epigenetics, and cancer.The hypomethylating agent decitabine prior to chemotherapy improves the therapy efficacy in refractory/relapsed acute myeloid leukemia patients.Regain control of p53: Targeting leukemia stem cells by isoform-specific HDAC inhibition Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia.MiR-424 and miR-27a increase TRAIL sensitivity of acute myeloid leukemia by targeting PLAG1 T-LAK cell-originated protein kinase presents a novel therapeutic target in FLT3-ITD mutated acute myeloid leukemia.The Wnt signaling pathway in cancer.Metabolic Modification in Gastrointestinal Cancer Stem Cells: Characteristics and Therapeutic Approaches.MicroRNA-494 Activation Suppresses Bone Marrow Stromal Cell-Mediated Drug Resistance in Acute Myeloid Leukemia Cells.c-Myc-miR-29c-REV3L signalling pathway drives the acquisition of temozolomide resistance in glioblastoma.LncRNA HULC triggers autophagy via stabilizing Sirt1 and attenuates the chemosensitivity of HCC cells.Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy.p53 inhibits the upregulation of sirtuin 1 expression induced by c-Myc.An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia Acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming.MicroRNAs and SIRT1: A Strategy for Stem Cell Renewal and Clinical Development?Tenovin-6 impairs autophagy by inhibiting autophagic flux.SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer.Targeting deubiquitinating enzymes in cancer stem cells.Pharmacologic Manipulation of Wnt Signaling and Cancer Stem Cells.Sirtuins at the crossroads of stemness, aging, and cancer.Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer.Pathogenesis and therapeutic targeting of aberrant MYC expression in haematological cancers.Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells.MZH29 is a novel potent inhibitor that overcomes drug resistance FLT3 mutations in acute myeloid leukemia.Repression of oxidative phosphorylation sensitizes leukemia cell lines to cytarabine.Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer.SIRT1 regulates Mxd1 during malignant melanoma progression.Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.Disruption of Wnt/β-catenin exerts anti-leukemia activity and synergizes with FLT3 inhibition in FLT3-mutant acute myeloid leukemia.A 17-gene stemness score for rapid determination of risk in acute leukaemia.

P2860

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P2860

SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells.

http://www.wikidata.org/entity/Q35009327

description

2014 nî lūn-bûn

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2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2014年の論文

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2014年論文

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2014年論文

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SIRT1 activation by a c-MYC on ...... e myeloid leukemia stem cells.

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J.STEM.2014.08.001

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SIRT1 activation by a c-MYC on ...... e myeloid leukemia stem cells.

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Allen Lin

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Cedric Dos Santos

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Hongfeng Yuan

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Jing Qi

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Liang Li

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Ling Li

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Mihaela Popa

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Puneet Agarwal

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Randi Hovland

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Ravi Bhatia

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P2860

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression

SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability

Acetylation is indispensable for p53 activation

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.

The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells

FLT3 as a therapeutic target in AML: still challenging after all these years

SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization

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431-446

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10.1016/J.STEM.2014.08.001

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4

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Emmet McCormack

Bjørn Tore Gjertsen

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2014-10-01T00:00:00Z

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269039805

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25280219

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4305398

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