New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases.
about
Toxicology of organophosphorus compounds in view of an increasing terrorist threat.Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification.Combined QSAR studies of inhibitor properties of O-phosphorylated oximes toward serine esterases involved in neurotoxicity, drug metabolism and Alzheimer's disease.Centrally acting oximes in reactivation of tabun-phosphoramidated AChE.Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugatesA comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides.Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches.Bispyridinium Compounds Inhibit Both Muscle and Neuronal Nicotinic Acetylcholine Receptors in Human Cell Lines.Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases.Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes.Kinetic assessment of N-methyl-2-methoxypyridinium species as phosphonate anion methylating agentsDrug development for the management of organophosphorus poisoning.New Cinchona Oximes Evaluated as Reactivators of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Organophosphorus Compounds.Post-exposure treatment with the oxime RS194B rapidly reverses early and advanced symptoms in macaques exposed to sarin vapor.SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides.Sarin (GB, O-isopropyl methylphosphonofluoridate) neurotoxicity: critical review.Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016).Mechanistic studies of new oximes reactivators of human butyryl cholinesterase inhibited by cyclosarin and sarin.Is it possible to reverse aged acetylcholinesterase inhibited by organophosphorus compounds? Insight from the theoretical study.Translation of in vitro to in vivo pyridinium oxime potential in tabun poisoning.Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation.Preclinical studies of noncharged oxime reactivators for organophosphate exposure.Post-exposure treatment with the oxime RS194B rapidly reactivates and reverses advanced symptoms of lethal inhaled paraoxon in macaques.Behavior of uncharged oximes compared to HI6 and 2-PAM in the human AChE-tabun conjugate: a molecular modeling approach.The biodistribution and pharmacokinetics of the oxime acetylcholinesterase reactivator RS194B in guinea pigs.Can hydroxylamine be a more potent nucleophile for the reactivation of tabun-inhibited AChE than prototype oxime drugs? An answer derived from quantum chemical and steered molecular dynamics studies.
P2860
Q30151953-1AEF5CB3-7113-4CF1-8751-B458B21F019FQ34202608-9ADDD4B3-7923-45BF-A953-D084F9A6D4CDQ34269625-44477165-5778-4136-A1B2-D469D6F2A9C1Q34409251-35BA129F-E98B-4160-AC6B-AC81AF44EF5AQ34414091-B7D106EA-16CE-4B0A-87AD-B5B2426E3A46Q34628506-6B1437FD-BA5E-4EBC-BB4C-6F8103C782A4Q35572473-6A7852DB-B70C-44E2-8636-601FBE4E32DAQ35746302-60903DD6-12F1-4DE2-816E-D10F65D39196Q35874368-5432DAEF-52A1-4049-8FDA-933409714033Q36635142-9B178C0B-DCED-45F7-AAD0-DE1A7E6AEB4CQ36937977-63F55FD2-F012-4D39-8987-C4ED043DF86DQ38152506-2DAF2D76-3BD1-4C4A-BF78-E593A3BFA5C0Q38652780-D81D0E46-7909-46C2-BA51-008ECBB7F874Q38685670-62B39E24-2254-47D1-89D7-47B7BC675597Q38942948-13F09623-F8D2-4224-BF6E-467CD8D1F89EQ38972692-C3B5FCBD-9409-43BD-9D48-9448D4476695Q39038234-6208C90A-AA68-4B21-A754-6F038CC4FE68Q39343521-998C0407-3443-4503-A3A6-571ED007E047Q39812909-8EE26F4F-59C7-40F8-9D77-464E43AEBEA4Q39900733-E7A7F803-E67F-45BE-8C1B-B5AD94863003Q40123151-C5B79D0D-BFBC-4056-9FC6-C9D2B4B9D6E1Q43969490-5E16DE37-01A5-4CCA-A409-7447BD935558Q45874550-E6934508-BE44-410A-9AEE-5A4FAC3F8F96Q46314151-B4A1C1F0-E286-4C04-A292-06F934AE1B72Q46376157-9B45BDCD-1C1E-433E-BC6C-5428CA348163Q46950790-8BF1B225-2F2B-444D-A06F-2BC865350B2FQ48695977-2E18DE22-A365-48CB-8CB4-9D18D885E1F1
P2860
New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases.
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
New structural scaffolds for c ...... phosphylated cholinesterases.
@ast
New structural scaffolds for c ...... phosphylated cholinesterases.
@en
type
label
New structural scaffolds for c ...... phosphylated cholinesterases.
@ast
New structural scaffolds for c ...... phosphylated cholinesterases.
@en
prefLabel
New structural scaffolds for c ...... phosphylated cholinesterases.
@ast
New structural scaffolds for c ...... phosphylated cholinesterases.
@en
P2093
P2860
P356
P1476
New structural scaffolds for c ...... phosphylated cholinesterases.
@en
P2093
Edzna Garcia
Gabriel Amitai
Limin Zhang
Maja Katalinić
Palmer Taylor
Rakesh K Sit
Valeria Gerardi
Zoran Radić
Zrinka Kovarik
P2860
P304
19422-19430
P356
10.1074/JBC.M111.230656
P407
P577
2011-04-04T00:00:00Z