In vivo crystallization of human IgG in the endoplasmic reticulum of engineered Chinese hamster ovary (CHO) cells.
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In cellulostructure determination of a novel cypovirus polyhedrinExploring the linkage between cell culture process parameters and downstream processing utilizing a plackett-burman design for a model monoclonal antibody.Giant crystals inside mitochondria of equine chondrocytes.In vivo crystallography at X-ray free-electron lasers: the next generation of structural biology?In vivo protein crystallization in combination with highly brilliant radiation sources offers novel opportunities for the structural analysis of post-translationally modified eukaryotic proteins.Real-time investigation of dynamic protein crystallization in living cells.Russell body phenotype is preferentially induced by IgG mAb clones with high intrinsic condensation propensity: relations between the biosynthetic events in the ER and solution behaviors in vitro.Clofazimine Biocrystal Accumulation in Macrophages Upregulates Interleukin 1 Receptor Antagonist Production To Induce a Systemic Anti-Inflammatory StateProteins improving recombinant antibody production in mammalian cells.Model-directed engineering of "difficult-to-express" monoclonal antibody production by Chinese hamster ovary cells.Vacuolar targeting of recombinant antibodies in Nicotiana benthamianaMicrocrystallography of Protein Crystals and In Cellulo Diffraction.Resolving self-association of a therapeutic antibody by formulation optimization and molecular approaches.Aggregates, crystals, gels, and amyloids: intracellular and extracellular phenotypes at the crossroads of immunoglobulin physicochemical property and cell physiology.Proteomic differences in recombinant CHO cells producing two similar antibody fragments.Enhanced IgG1 production by overexpression of nuclear factor kappa B inhibitor zeta (NFKBIZ) in Chinese hamster ovary cells.Intermolecular interactions involving an acidic patch on immunoglobulin variable domain and the γ2 constant region mediate crystalline inclusion body formation in the endoplasmic reticulum.Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic.Fast and scalable purification of a therapeutic full-length antibody based on process crystallization.Overexpression of cryoglobulin-like single-chain antibody induces morular cell phenotype via liquid-liquid phase separation in the secretory pathway organelles.Uncovering methods for the prevention of protein aggregation and improvement of product quality in a transient expression system.
P2860
Q27683719-F6C7DBC3-FF3B-46AE-AF1B-6D5D3FA0E53EQ30394880-A60EE4EE-B1CB-4505-B3F4-8A9B3C68B14EQ33592095-78483644-D081-4E4F-A5D3-FCE07BDE3B07Q33738426-24515164-72A8-4DDF-9646-990758211B4BQ35739289-C1F578D3-8347-4567-AE65-C21B9B5DD487Q35900994-1DC7984F-86A0-4781-B69E-6E14B9C08FFDQ36212910-8DC9ECFC-80C9-4168-9545-8B3A79D89108Q36933396-D31A0339-8246-4B2D-B0C9-2F007B4AD7A5Q38170315-63566813-0666-4FE8-891F-609398CC5F3AQ39089474-CC51BAAA-C726-4709-A86E-79B09DBBC071Q39783061-180CACE4-F8B9-4E4B-902A-E7ABF0F4B3AAQ40103005-D7CB5958-9F7C-41B2-AAA0-FBC55A4CFBDCQ41718661-F46ED431-7691-4978-B42C-5F413342FF80Q41831737-18BA79A0-5434-4A4F-9125-6A5F8F2C66F1Q42355436-991EDE28-24B2-40B7-8D45-B2FE42D0543FQ47300551-3A955BD0-6ABC-4CC3-9BF8-25B6B08E58F1Q47750545-C9E91B63-3F0F-441E-9E00-66C28650DE93Q51070881-373153A2-F04C-4F14-BE43-A7EE17EF10DFQ51754011-1EF35494-9C52-44D9-B10D-6917887EB39AQ52660613-E88EA9B4-F0DB-430E-950C-4B81DBC70B51Q53004283-E943E91D-7829-4A9C-BC2A-DE3FF54A5DB3
P2860
In vivo crystallization of human IgG in the endoplasmic reticulum of engineered Chinese hamster ovary (CHO) cells.
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
In vivo crystallization of hum ...... ese hamster ovary (CHO) cells.
@ast
In vivo crystallization of hum ...... ese hamster ovary (CHO) cells.
@en
type
label
In vivo crystallization of hum ...... ese hamster ovary (CHO) cells.
@ast
In vivo crystallization of hum ...... ese hamster ovary (CHO) cells.
@en
prefLabel
In vivo crystallization of hum ...... ese hamster ovary (CHO) cells.
@ast
In vivo crystallization of hum ...... ese hamster ovary (CHO) cells.
@en
P2093
P2860
P356
P1476
In vivo crystallization of hum ...... nese hamster ovary (CHO) cells
@en
P2093
Deirdre Murphy Piedmonte
Egor Trilisky
Francis Kinderman
Heather Franey
John Wendling
Randal R Ketchem
Riki Stevenson
P2860
P304
19917-19931
P356
10.1074/JBC.M110.204362
P407
P577
2011-04-04T00:00:00Z