Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1 - Wikidata - awgldk - TriplyDB

Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1

Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1

http://www.wikidata.org/entity/Q35019240

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Enhancing energy and glucose metabolism by disrupting triglyceride synthesis: Lessons from mice lacking DGAT1.Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolism Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure.Diacylglycerol acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release.The alternative stimulatory G protein alpha-subunit XLalphas is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids.Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin.Phenotypic population screen identifies a new mutation in bovine DGAT1 responsible for unsaturated milk fat Transplantation of adipose tissue and stem cells: role in metabolism and disease Improved glucose tolerance in acyl CoA:diacylglycerol acyltransferase 1-null mice is dependent on diet.DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle.Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance.Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.The role of acyl-CoA:diacylglycerol acyltransferase (DGAT) in energy metabolism.Nonequilibrium thermodynamics and energy efficiency in weight loss diets.Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking renin.Adipose targets for obesity drug development.The fatty acid oxidation pathway as a therapeutic target for insulin resistance.Regulation of triglyceride metabolism. I. Eukaryotic neutral lipid synthesis: "Many ways to skin ACAT or a DGAT".p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.Evidence for a role of LPGAT1 in influencing BMI and percent body fat in Native Americans.Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation SCD1 activity in muscle increases triglyceride PUFA content, exercise capacity, and PPARδ expression in mice The genetics of neutral lipid biosynthesis: an evolutionary perspective Role of adipocyte-derived apoE in modulating adipocyte size, lipid metabolism, and gene expression in vivo.Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues.DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1.Topological orientation of acyl-CoA:diacylglycerol acyltransferase-1 (DGAT1) and identification of a putative active site histidine and the role of the n terminus in dimer/tetramer formation.Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors.Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release--potential insight into mechanism of action.Intestinal failure and aberrant lipid metabolism in patients with DGAT1 deficiency.Cell suspension culture of Eriobotrya japonica regulates the diabetic and hyperlipidemic signs of high-fat-fed mice.Evidence for a Role of LPGAT1 in Influencing BMI and Percent Body Fat in Native Americans

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P2860

Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1

http://www.wikidata.org/entity/Q35019240

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2003 nî lūn-bûn

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2003 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2003 թվականի հունիսին հրատարակված գիտական հոդված

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2003年の論文

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Obesity resistance and enhance ...... acylglycerol acyltransferase 1

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Dalan R Jensen

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Heather M Myers

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Hubert C Chen

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Robert H Eckel

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Robert V Farese

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P2860

Positional cloning of the mouse obese gene and its human homologue

Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

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