Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1
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Enhancing energy and glucose metabolism by disrupting triglyceride synthesis: Lessons from mice lacking DGAT1.Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolismLipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanismsCardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure.Diacylglycerol acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release.The alternative stimulatory G protein alpha-subunit XLalphas is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult miceThematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids.Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin.Phenotypic population screen identifies a new mutation in bovine DGAT1 responsible for unsaturated milk fatTransplantation of adipose tissue and stem cells: role in metabolism and diseaseImproved glucose tolerance in acyl CoA:diacylglycerol acyltransferase 1-null mice is dependent on diet.DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle.Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance.Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.The role of acyl-CoA:diacylglycerol acyltransferase (DGAT) in energy metabolism.Nonequilibrium thermodynamics and energy efficiency in weight loss diets.Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking renin.Adipose targets for obesity drug development.The fatty acid oxidation pathway as a therapeutic target for insulin resistance.Regulation of triglyceride metabolism. I. Eukaryotic neutral lipid synthesis: "Many ways to skin ACAT or a DGAT".p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.Evidence for a role of LPGAT1 in influencing BMI and percent body fat in Native Americans.Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolismInactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammationSCD1 activity in muscle increases triglyceride PUFA content, exercise capacity, and PPARδ expression in miceThe genetics of neutral lipid biosynthesis: an evolutionary perspectiveRole of adipocyte-derived apoE in modulating adipocyte size, lipid metabolism, and gene expression in vivo.Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues.DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicityDiscovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1.Topological orientation of acyl-CoA:diacylglycerol acyltransferase-1 (DGAT1) and identification of a putative active site histidine and the role of the n terminus in dimer/tetramer formation.Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors.Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release--potential insight into mechanism of action.Intestinal failure and aberrant lipid metabolism in patients with DGAT1 deficiency.Cell suspension culture of Eriobotrya japonica regulates the diabetic and hyperlipidemic signs of high-fat-fed mice.Evidence for a Role of LPGAT1 in Influencing BMI and Percent Body Fat in Native Americans
P2860
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P2860
Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Obesity resistance and enhance ...... acylglycerol acyltransferase 1
@ast
Obesity resistance and enhance ...... acylglycerol acyltransferase 1
@en
type
label
Obesity resistance and enhance ...... acylglycerol acyltransferase 1
@ast
Obesity resistance and enhance ...... acylglycerol acyltransferase 1
@en
prefLabel
Obesity resistance and enhance ...... acylglycerol acyltransferase 1
@ast
Obesity resistance and enhance ...... acylglycerol acyltransferase 1
@en
P2093
P2860
P356
P1476
Obesity resistance and enhance ...... acylglycerol acyltransferase 1
@en
P2093
Dalan R Jensen
Heather M Myers
Hubert C Chen
Robert H Eckel
Robert V Farese
P2860
P304
P356
10.1172/JCI15859
P407
P577
2003-06-01T00:00:00Z