Proteolytic degradation of MAD3 (I kappa B alpha) and enhanced processing of the NF-kappa B precursor p105 are obligatory steps in the activation of NF-kappa B.
about
Atypical IκB proteins - nuclear modulators of NF-κB signalingRegulation of IkappaBalpha function and NF-kappaB signaling: AEBP1 is a novel proinflammatory mediator in macrophagesCoupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activationRepression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP betaIkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase.Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalphaPhosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuliMapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradationControl of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alphaNF-κB, the first quarter-century: remarkable progress and outstanding questionsDual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processingbetaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.Ubiquitination and degradation of the inhibitors of NF-kappaBSuppression of tumor necrosis factor-α-induced nuclear factor κB activation and aromatase activity by capsaicin and its analog capsazepineTax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa BAll three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complexInducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitorsAntiapoptotic role of NF-kappaB in the auto-oxidized dopamine-induced apoptosis of PC12 cells.Identification of a NFKBIA polymorphism associated with lower NFKBIA protein levels and poor survival outcomes in patients with glioblastoma multiforme.Metabolism and action of proteasome inhibitors in primary human hepatocytesIdentification and validation of p50 as the cellular target of eriocalyxin B.Functions of NF-kappaB1 and NF-kappaB2 in immune cell biologyInhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression.Cell cycle-regulated expression of the muscle determination factor Myf5 in proliferating myoblasts.Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells.In vivo stimulation of I kappa B phosphorylation is not sufficient to activate NF-kappa BTranscription-independent turnover of I kappa B alpha during monocyte adherence: implications for a translational component regulating I kappa B alpha/MAD-3 mRNA levels.Inducible nuclear expression of newly synthesized I kappa B alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa B.N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity.A glycine-rich region in NF-kappaB p105 functions as a processing signal for the generation of the p50 subunitDifferential regulation of NF-kappaB2(p100) processing and control by amino-terminal sequences.Reconstitution of the NF-kappa B system in Saccharomyces cerevisiae for isolation of effectors by phenotype modulation.Old target new approach: an alternate NF-kappaB activation pathway via translation inhibition.Inhibition of bovine endothelial cell activation in vitro by regulated expression of a transdominant inhibitor of NF-kappa B.Liver kinase B1 is required for thromboxane receptor-dependent nuclear factor-κB activation and inflammatory responses.The kinase NIK as a therapeutic target in multiple myeloma.It takes two to tango: IκBs, the multifunctional partners of NF-κB.Regulation of NF-κB by ubiquitination and degradation of the IκBs.NF-κB and the link between inflammation and cancer.
P2860
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P2860
Proteolytic degradation of MAD3 (I kappa B alpha) and enhanced processing of the NF-kappa B precursor p105 are obligatory steps in the activation of NF-kappa B.
description
1993 nî lūn-bûn
@nan
1993 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Proteolytic degradation of MAD ...... the activation of NF-kappa B.
@ast
Proteolytic degradation of MAD ...... the activation of NF-kappa B.
@en
type
label
Proteolytic degradation of MAD ...... the activation of NF-kappa B.
@ast
Proteolytic degradation of MAD ...... the activation of NF-kappa B.
@en
prefLabel
Proteolytic degradation of MAD ...... the activation of NF-kappa B.
@ast
Proteolytic degradation of MAD ...... the activation of NF-kappa B.
@en
P2093
P2860
P356
P1476
Proteolytic degradation of MAD ...... the activation of NF-kappa B.
@en
P2093
P2860
P304
P356
10.1093/NAR/21.22.5059
P407
P577
1993-11-01T00:00:00Z