Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor.
about
The Stability and Expression Level of Bok Are Governed by Binding to Inositol 1,4,5-Trisphosphate ReceptorsThe trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition.Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment.Bcl-2 proteins and calcium signaling: complexity beneath the surface.Synergistic killing of human small cell lung cancer cells by the Bcl-2-inositol 1,4,5-trisphosphate receptor disruptor BIRD-2 and the BH3-mimetic ABT-263.Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.Organelle membrane derived patches: reshaping classical methods for new targetsA double point mutation at residues Ile14 and Val15 of Bcl-2 uncovers a role for the BH4 domain in both protein stability and function.Electroporation Loading and Dye Transfer: A Safe and Robust Method to Probe Gap Junctional Coupling.BH4 domain peptides derived from Bcl-2/Bcl-XL as novel tools against acute pancreatitis.
P2860
Q28590558-73AD75D6-CBA0-4F38-8D12-AA2776664658Q37688303-D921E22B-AF4E-46E7-947F-0BB60B2E43A4Q38398064-C1BD450F-B1FC-4443-8260-B81394C3318DQ38773462-B3F5B7D1-A813-44BF-B16E-610478295963Q38807526-C60BC163-D635-46E4-90C2-07B12D23D11AQ41432708-B3AAEC9A-3BF8-4ACF-BE89-59CAEFF1E17BQ42620650-E4A4C869-3683-4628-A5B6-818BB98092A6Q47409394-6BAB7B0B-AA3D-46DF-8C02-0100B9FC0605Q49047593-2FA2586C-E5C1-4074-B7F8-24E21F3A20C2Q54943530-48BFC59C-0EC4-4A65-9510-0C7F246B6290
P2860
Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor.
description
2013 nî lūn-bûn
@nan
2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Alpha-helical destabilization ...... y to inhibit the IP3 receptor.
@ast
Alpha-helical destabilization ...... y to inhibit the IP3 receptor.
@en
type
label
Alpha-helical destabilization ...... y to inhibit the IP3 receptor.
@ast
Alpha-helical destabilization ...... y to inhibit the IP3 receptor.
@en
prefLabel
Alpha-helical destabilization ...... y to inhibit the IP3 receptor.
@ast
Alpha-helical destabilization ...... y to inhibit the IP3 receptor.
@en
P2093
P2860
P50
P1433
P1476
Alpha-helical destabilization ...... y to inhibit the IP3 receptor.
@en
P2093
David I Yule
Elke Decrock
Humbert De Smedt
Larry E Wagner
Ludwig Missiaen
Sergei V Strelkov
Tomas Luyten
P2860
P304
P356
10.1371/JOURNAL.PONE.0073386
P407
P577
2013-08-30T00:00:00Z