Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice - Wikidata - awgldk - TriplyDB

Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice

Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice

http://www.wikidata.org/entity/Q35040534

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Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology Genetic ablation of Nrf2/antioxidant response pathway in Alexander disease mice reduces hippocampal gliosis but does not impact survival Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics.Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease.Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training.Nrf2 enhances myocardial clearance of toxic ubiquitinated proteins Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities Reductive potential - a savior turns stressor in protein aggregation cardiomyopathy Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.Proteostasis and REDOX state in the heart.Small heat shock proteins in redox metabolism: implications for cardiovascular diseases.Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice Reductive stress linked to small HSPs, G6PD, and Nrf2 pathways in heart disease Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress.Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: a mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle Loss of Mrp1 Potentiates Doxorubicin-Induced Cytotoxicity in Neonatal Mouse Cardiomyocytes and Cardiac Fibroblasts Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium.Nrf2 and cardiovascular defense.Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases.Contribution of small heat shock proteins to muscle development and function.Role of the Nrf2 signaling system in health and disease.Heme oxygenase-1: an emerging therapeutic target to curb cardiac pathology.Diabetic cardiomyopathy and its prevention by nrf2: current status.KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity.Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated protein quality control in cardiomyocytes.Mediterranean diet and inflammaging within the hormesis paradigm.Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium.Responses to reductive stress in the cardiovascular system.Aggregate-prone R120GCRYAB triggers multifaceted modifications of the thioredoxin system.Identification of transcriptome signature for myocardial reductive stress.Nrf2 deficiency promotes apoptosis and impairs PAX7/MyoD expression in aging skeletal muscle cells.The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus.Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy.Reductive Stress in Inflammation-Associated Diseases and the Pro-Oxidant Effect of Antioxidant Agents.Increasing autophagy and blocking Nrf2 suppress laminopathy-induced age-dependent cardiac dysfunction and shortened lifespan.NRF2 Induction for NASH Treatment: A New Hope Rises.Carnosic acid promotes myocardial antioxidant response and prevents isoproterenol-induced myocardial oxidative stress and apoptosis in mice.

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P2860

Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice

http://www.wikidata.org/entity/Q35040534

description

2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Sustained activation of nuclea ...... egation cardiomyopathy in mice

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Sustained activation of nuclea ...... egation cardiomyopathy in mice

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type

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Sustained activation of nuclea ...... egation cardiomyopathy in mice

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Sustained activation of nuclea ...... egation cardiomyopathy in mice

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prefLabel

Sustained activation of nuclea ...... egation cardiomyopathy in mice

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Sustained activation of nuclea ...... egation cardiomyopathy in mice

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Antioxidants & Redox Signaling

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Sustained activation of nuclea ...... egation cardiomyopathy in mice

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Christopher J Davidson

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Gayatri D Khanderao

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Ivor J Benjamin

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Jay L Zweier

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Matthew A Firpo

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Namakkal Soorappan Rajasekaran

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Sankaranarayanan Kannan

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Saradhadevi Varadharaj

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P2860

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

Nrf2-Keap1 defines a physiologically important stress response mechanism

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

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957-971

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10.1089/ARS.2010.3587

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6

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14

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49653124

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21126175

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3113450

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