Pharmacological approach towards the development of indolequinone bioreductive drugs based on the clinically inactive agent EO9.

Pharmacological approach towards the development of indolequinone bioreductive drugs based on the clinically inactive agent EO9.

Item
http://www.wikidata.org/entity/Q35044683
Implications of NQO1 in cancer therapyUpregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells.EO9 (Apaziquone): from the clinic to the laboratory and back againTaking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies.NQO1 inhibits proteasome-mediated degradation of HIF-1α.Versatile carboxymethyl chitin and chitosan nanomaterials: a review.Efficacy, pharmacokinetic and pharmacodynamic evaluation of apaziquone in the treatment of non-muscle invasive bladder cancer.Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer.Synthesis-enabled probing of mitosene structural space leads to improved IC₅₀ over mitomycin C.Hyperthermia enhances the effect of β-lapachone to cause γH2AX formations and cell death in human osteosarcoma cells.Heat shock increases expression of NAD(P)H:quinone oxidoreductase (NQO1), mediator of beta-lapachone cytotoxicity, by increasing NQO1 gene activity and via Hsp70-mediated stabilisation of NQO1 protein.Anti-cancer effect of bio-reductive drug beta-lapachon is enhanced by activating NQO1 with heat shock.A Model for NAD(P)H:Quinoneoxidoreductase 1 (NQO1) Targeted Individualized Cancer Chemotherapy.The efficacy of Apaziquone in the treatment of bladder cancer.Mesoporous nanocarriers with a stimulus-responsive cyclodextrin gatekeeper for targeting tumor hypoxia.
P2860

Pharmacological approach towards the development of indolequinone bioreductive drugs based on the clinically inactive agent EO9.

Item
http://www.wikidata.org/entity/Q35044683
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Pharmacological approach towar ...... clinically inactive agent EO9.
@en
type
label
Pharmacological approach towar ...... clinically inactive agent EO9.
@en
prefLabel
Pharmacological approach towar ...... clinically inactive agent EO9.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
Pharmacological approach towar ...... clinically inactive agent EO9
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932