Transcription-induced DNA double strand breaks: both oncogenic force and potential therapeutic target? - Wikidata - awgldk - TriplyDB

Transcription-induced DNA double strand breaks: both oncogenic force and potential therapeutic target?

Transcription-induced DNA double strand breaks: both oncogenic force and potential therapeutic target?

http://www.wikidata.org/entity/Q35053261

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TRIM28 as a novel transcriptional elongation factor The convergence of DNA damage checkpoint pathways and androgen receptor signaling in prostate cancer Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer GATA3 cooperates with PARP1 to regulate CCND1 transcription through modulating histone H1 incorporation.HP1β-dependent recruitment of UBF1 to irradiated chromatin occurs simultaneously with CPDs.BRAF mutation is associated with a specific cell type with features suggestive of senescence in ovarian serous borderline (atypical proliferative) tumors Inferring the temporal order of cancer gene mutations in individual tumor samples High level of chromosomal aberration in ovarian cancer genome correlates with poor clinical outcome Mutant BRAF induces DNA strand breaks, activates DNA damage response pathway, and up-regulates glucose transporter-1 in nontransformed epithelial cells.Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes.Tissue-specific tumorigenesis: context matters.Androgen pathway resistance in prostate cancer and therapeutic implications Nucleotide resolution analysis of TMPRSS2 and ERG rearrangements in prostate cancer.Androgen Deprivation Followed by Acute Androgen Stimulation Selectively Sensitizes AR-Positive Prostate Cancer Cells to Ionizing Radiation.Defining chromosomal translocation risks in cancer.Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy.Maintenance of genomic integrity after DNA double strand breaks in the human prostate and seminal vesicle epithelium: the best and the worst.TMPRSS2-ERG Fusion Gene Expression in Prostate Tumor Cells and Its Clinical and Biological Significance in Prostate Cancer Progression Plant hormone signaling and modulation of DNA repair under stressful conditions.Maintaining and reprogramming genomic androgen receptor activity in prostate cancer.Topoisomerase-mediated chromosomal break repair: an emerging player in many games.INO80 Chromatin Remodeler Facilitates Release of RNA Polymerase II from Chromatin for Ubiquitin-Mediated Proteasomal Degradation.Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells The Role of Testosterone in the Treatment of Castration-Resistant Prostate Cancer.Trouble in transitioning: activation of zygotic transcription can lead to DNA breakage and genome instability Effect of bipolar androgen therapy for asymptomatic men with castration-resistant prostate cancer: results from a pilot clinical study.Combinatorial antitumor effect of HDAC and the PI3K-Akt-mTOR pathway inhibition in a Pten defecient model of prostate cancer Microhomology-mediated intron loss during metazoan evolution.Beefing up prostate cancer therapy with performance-enhancing (anti-) steroids.Mycofumigation by the volatile organic compound-producing Fungus Muscodor albus induces bacterial cell death through DNA damage.Determination of synthetic lethal interactions to provide therapeutic direction to end aggressive prostate cancer.The inflammatory microenvironment and microbiome in prostate cancer development.DNA double-strand breaks: linking gene expression to chromosome morphology and mobility.Mitochondrial tyrosyl-DNA phosphodiesterase 2 and its TDP2S short isoform.Developmental epigenetic programming of adult germ cell death disease: Polycomb protein EZH2-miR-101 pathway.The structure of the nucleus in normal and neoplastic prostate cells: untangling the role of type 2 DNA topoisomerases.TET1 deficiency attenuates the DNA damage response and promotes resistance to DNA damaging agents.Association of ERG and TMPRSS2-ERG with grade, stage, and prognosis of prostate cancer is dependent on their expression levels.Recent advances in prostate cancer research: large-scale genomic analyses reveal novel driver mutations and DNA repair defects

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P2860

Transcription-induced DNA double strand breaks: both oncogenic force and potential therapeutic target?

http://www.wikidata.org/entity/Q35053261

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Transcription-induced DNA doub ...... potential therapeutic target?

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Transcription-induced DNA doub ...... potential therapeutic target?

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Transcription-induced DNA doub ...... potential therapeutic target?

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Transcription-induced DNA doub ...... potential therapeutic target?

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Transcription-induced DNA doub ...... potential therapeutic target?

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Clinical Cancer Research

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Transcription-induced DNA doub ...... potential therapeutic target?

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Alan K Meeker

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Angelo M De Marzo

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Michael C Haffner

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Srinivasan Yegnasubramanian

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William G Nelson

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P2860

Cellular roles of dna topoisomerases: a molecular perspective

TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage

A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

A role of DNA-PK for the metabolic gene regulation in response to insulin

Subnuclear localization of Ku protein: functional association with RNA polymerase II elongation sites.

Human prostate tumor growth in athymic mice: inhibition by androgens and stimulation by finasteride

The DNA-damage response in human biology and disease

Targeting DNA topoisomerase II in cancer chemotherapy

Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia

Estrogen as therapy for breast cancer.

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