WIP1 phosphatase as a potential therapeutic target in neuroblastoma - Wikidata - awgldk - TriplyDB

WIP1 phosphatase as a potential therapeutic target in neuroblastoma

WIP1 phosphatase as a potential therapeutic target in neuroblastoma

http://www.wikidata.org/entity/Q35058327

about

Targeting the Checkpoint to Kill Cancer Cells Pathology, Molecular Genetics, and Epigenetics of Diffuse Intrinsic Pontine Glioma Wip1 phosphatase: between p53 and MAPK kinases pathways Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy WIP1 phosphatase as pharmacological target in cancer therapy.NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis Wip1 inhibitor GSK2830371 inhibits neuroblastoma growth by inducing Chk2/p53-mediated apoptosis.Dynamics of p53: A Master Decider of Cell Fate.Novel MDM2 inhibitor SAR405838 (MI-773) induces p53-mediated apoptosis in neuroblastoma.Wild-type p53-induced phosphatase 1 is a prognostic marker and therapeutic target in bladder transitional cell carcinoma.Wip1 regulates SKOV3 cell apoptosis through the p38 MAPK signaling pathway.Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner.Wip1 is associated with tumorigenity and metastasis through MMP-2 in human intrahepatic cholangiocarcinoma.Role of wild-type p53-induced phosphatase 1 in cancer Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3.The pathophysiological significance of PPM1D and therapeutic targeting of PPM1D-mediated signaling by GSK2830371 in mantle cell lymphoma Arsenic trioxide induces cell cycle arrest and affects Trk receptor expression in human neuroblastoma SK-N-SH cells.

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P2860

WIP1 phosphatase as a potential therapeutic target in neuroblastoma

http://www.wikidata.org/entity/Q35058327

description

2015 nî lūn-bûn

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2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2015年の論文

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2015年学术文章

@wuu

2015年学术文章

@zh-cn

2015年学术文章

@zh-hans

2015年学术文章

@zh-my

2015年学术文章

@zh-sg

2015年學術文章

@yue

name

WIP1 phosphatase as a potential therapeutic target in neuroblastoma

@ast

WIP1 phosphatase as a potential therapeutic target in neuroblastoma

@en

type

label

WIP1 phosphatase as a potential therapeutic target in neuroblastoma

@ast

WIP1 phosphatase as a potential therapeutic target in neuroblastoma

@en

prefLabel

WIP1 phosphatase as a potential therapeutic target in neuroblastoma

@ast

WIP1 phosphatase as a potential therapeutic target in neuroblastoma

@en

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JOURNAL.PONE.0115635

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WIP1 phosphatase as a potential therapeutic target in neuroblastoma

@en

P2093

Aidan G Gilmartin

http://www.w3.org/2001/XMLSchema#string

Gopinath Ganji

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Harjeet Van Der Key

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Jason M Shohet

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Lawrence A Donehower

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Mark Richter

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Rakesh Kumar

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Sandhya Kiran Pemmasani

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Tajhal Dayaram

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P2860

Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

Substrate specificity of the human protein phosphatase 2Cdelta, Wip1

The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours

Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome

Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma

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e0115635

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scholarly article

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10.1371/JOURNAL.PONE.0115635

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2

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