Retroviral vectors containing putative internal ribosome entry sites: development of a polycistronic gene transfer system and applications to human gene therapy.
about
KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels.KCNE4 is an inhibitory subunit to the KCNQ1 channelTransfer of single gene-containing long terminal repeats into the genome of mammalian cells by a retroviral vector carrying the cre gene and the loxP siteInhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptidesInternal ribosome entry site-based vectors for combined gene therapyMultiple SH3 domain interactions regulate NADPH oxidase assembly in whole cells.Fusagene vectors: a novel strategy for the expression of multiple genes from a single cistron.Cytochrome P450-based cancer gene therapy: recent advances and future prospects.Selection of transduced CD34+ progenitors and enzymatic correction of cells from Gaucher patients, with bicistronic vectorsDevelopment of multigene and regulated lentivirus vectors.Identification of an internal ribosome entry segment in the 5' region of the mouse VL30 retrotransposon and its use in the development of retroviral vectorsConstruction of retroviral vectors with improved safety, gene expression, and versatility.Human T-cell leukemia virus type 1 expressing nonoverlapping tax and rex genes replicates and immortalizes primary human T lymphocytes but fails to replicate and persist in vivo.The molecular and functional interaction between ICln and HSPC038 proteins modulates the regulation of cell volume.Recognition of fresh human tumor by human peripheral blood lymphocytes transduced with a bicistronic retroviral vector encoding a murine anti-p53 TCR.Transfer of a TCR gene derived from a patient with a marked antitumor response conveys highly active T-cell effector functions.Retrovirus-mediated gene transfer to cystic fibrosis airway epithelial cells: effect of selectable marker sequences on long-term expressionDrug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector.An internal ribosomal entry signal in the rat VL30 region of the Harvey murine sarcoma virus leader and its use in dicistronic retroviral vectors.In vivo study of genetically simplified bovine leukemia virus derivatives that lack tax and rexDevelopment of 2A peptide-based strategies in the design of multicistronic vectors.Lethiferous effects of a recombinant vector carrying thymidine kinase suicide gene on 2.2.15 cells via a self-modulating mechanism.Primary human lymphocytes transduced with NY-ESO-1 antigen-specific TCR genes recognize and kill diverse human tumor cell linesMis-targeting of the mitochondrial protein LIPT2 leads to apoptotic cell deathHigh efficiency TCR gene transfer into primary human lymphocytes affords avid recognition of melanoma tumor antigen glycoprotein 100 and does not alter the recognition of autologous melanoma antigens.Pharmacokinetics of combined gene therapy expressing constitutive human GM-CSF and hyperthermia-regulated human IL-12Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognitionRegulated multicistronic expression technology for mammalian metabolic engineering.Size matters: versatile use of PiggyBac transposons as a genetic manipulation tool.Composition and arrangement of genes define the strength of IRES-driven translation in bicistronic mRNAs.High-titer bicistronic retroviral vectors employing foot-and-mouth disease virus internal ribosome entry site.Novel retroviral vector transferring a suicide gene and a selectable marker gene with enhanced gene expression by using a tetracycline-responsive expression system.Murine leukemia virus-based Tat-inducible long terminal repeat replacement vectors: a new system for anti-human immunodeficiency virus gene therapy.Lack of correlation between basal expression levels and susceptibility to transcriptional shutdown among single-gene murine leukemia virus vector proviruses.Picornavirus internal ribosome entry segments: comparison of translation efficiency and the requirements for optimal internal initiation of translation in vitro.An RNA secondary structure bias for non-homologous reverse transcriptase-mediated deletions in vivoComparison of HSV-1 thymidine kinase-dependent and -independent inhibition of replication-competent adenoviral vectors by a panel of drugs.Increased functional expression of transgene in primary human lymphocytes using retroviral vectors modified with IRES and splicing motifs.A tricistronic retroviral vector expressing natural antiangiogenic factors inhibits angiogenesis in vitro, but is not able to block tumor progression in vivo.Transplants of cells genetically modified to express neurotrophin-3 rescue axotomized Clarke's nucleus neurons after spinal cord hemisection in adult rats.
P2860
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P2860
Retroviral vectors containing putative internal ribosome entry sites: development of a polycistronic gene transfer system and applications to human gene therapy.
description
1992 nî lūn-bûn
@nan
1992 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի մարտին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Retroviral vectors containing ...... cations to human gene therapy.
@ast
Retroviral vectors containing ...... cations to human gene therapy.
@en
type
label
Retroviral vectors containing ...... cations to human gene therapy.
@ast
Retroviral vectors containing ...... cations to human gene therapy.
@en
prefLabel
Retroviral vectors containing ...... cations to human gene therapy.
@ast
Retroviral vectors containing ...... cations to human gene therapy.
@en
P2093
P2860
P356
P1476
Retroviral vectors containing ...... cations to human gene therapy.
@en
P2093
P2860
P304
P356
10.1093/NAR/20.6.1293
P407
P577
1992-03-01T00:00:00Z