Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a novel GPR30-dependent Mechanism - Wikidata - awgldk - TriplyDB

Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a novel GPR30-dependent Mechanism

Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a novel GPR30-dependent Mechanism

http://www.wikidata.org/entity/Q35072737

about

Emerging from the bottleneck: benefits of the comparative approach to modern neuroscience Estrogen biology: new insights into GPER function and clinical opportunities Contributions of academic laboratories to the discovery and development of chemical biology tools An NO donor approach to neuroprotective and procognitive estrogen therapy overcomes loss of NO synthase function and potentially thrombotic risk G-protein oestrogen receptor 1: trials and tribulations of a membrane oestrogen receptor Astrocyte-derived growth factors and estrogen neuroprotection: role of transforming growth factor-α in estrogen-induced upregulation of glutamate transporters in astrocytes Mechanism of raloxifene-induced upregulation of glutamate transporters in rat primary astrocytes GPER/GPR30 and Regulation of Vascular Tone and Blood Pressure.SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites.Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer.Role of nociceptor estrogen receptor GPR30 in a rat model of endometriosis pain.Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation.Estrogen receptor agonists for attenuation of neuroinflammation and neurodegeneration.The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function.International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes GPER1/GPR30 activation improves neuronal survival following global cerebral ischemia induced by cardiac arrest in mice.A chimeric SERM-histone deacetylase inhibitor approach to breast cancer therapy.Neuroprotection and estrogen receptors.Novel Selective Estrogen Receptor Downregulators (SERDs) Developed against Treatment-Resistant Breast Cancer.Tamoxifen Provides Structural and Functional Rescue in Murine Models of Photoreceptor Degeneration.Effects of estrogen receptor modulators on cytoskeletal proteins in the central nervous system.17β-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity.Effects of Ovariectomy in an hSOD1-G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis (ALS).Characterization of the G-protein-coupled membrane-bound estrogen receptor GPR30 in the zebra finch brain reveals a sex difference in gene and protein expression.In Vitro Neuroprotective and Anti-Inflammatory Activities of Natural and Semi-Synthetic Spirosteroid Analogues.Translational Significance of Selective Estrogen Receptor Modulators in Psychiatric Disorders

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Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a novel GPR30-dependent Mechanism

http://www.wikidata.org/entity/Q35072737

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2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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Benzothiophene Selective Estro ...... ovel GPR30-dependent Mechanism

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Benzothiophene Selective Estro ...... ovel GPR30-dependent Mechanism

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Benzothiophene Selective Estro ...... ovel GPR30-dependent Mechanism

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Benzothiophene Selective Estro ...... ovel GPR30-dependent Mechanism

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ACS Chemical Neuroscience

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Benzothiophene Selective Estro ...... ovel GPR30-dependent Mechanism

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Bradley Michalsen

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Gregory R J Thatcher

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Indraneel Kundu

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Isaac T Schiefer

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Jia Luo

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Lawren Vandevrede

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Ping Yao

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Ramy Abdelhamid

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Teshome Gherezghiher

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Vladislav A Litosh

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Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial

Ischemic cell death in brain neurons

Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial

Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action

Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons

Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination

Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF

Clinical trials with neuroprotective drugs in acute ischaemic stroke: are we doing the right thing?

Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function

Postmenopausal hormone therapy and cognitive outcomes: the Women's Health Initiative Memory Study (WHIMS).

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256-268

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10.1021/CN100106A

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5

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2

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51469836

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21731800

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