Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cells.

Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cells.

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http://www.wikidata.org/entity/Q35076645

Q35076645

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Redefining the viral reservoirs that prevent HIV-1 eradication New tools for quantifying HIV-1 reservoirs: plasma RNA single copy assays and beyond Residual viremia in an RT-SHIV rhesus macaque HAART model marked by the presence of a predominant plasma clone and a lack of viral evolution Residual Viremia in Treated HIV+ Individuals Intensification of antiretroviral therapy with a CCR5 antagonist in patients with chronic HIV-1 infection: effect on T cells latently infected Dendritic cells restore CD8+ T cell reactivity to autologous HIV-1 HIV-1 low-level viraemia assessed with 3 commercial real-time PCR assays show high variability.Incomplete adherence to antiretroviral therapy is associated with higher levels of residual HIV-1 viremia.HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection.Improved single-copy assays for quantification of persistent HIV-1 viremia in patients on suppressive antiretroviral therapy.Eradicating HIV-1 infection: seeking to clear a persistent pathogen.Latent HIV-1 infection of resting CD4⁺ T cells in the humanized Rag2⁻/⁻ γc⁻/⁻ mouse Baseline cellular HIV DNA load predicts HIV DNA decline and residual HIV plasma levels during effective antiretroviral therapy.Absence of HIV-1 evolution in the gut-associated lymphoid tissue from patients on combination antiviral therapy initiated during primary infection.Plasma CXCL10, sCD163 and sCD14 Levels Have Distinct Associations with Antiretroviral Treatment and Cardiovascular Disease Risk Factors.Immediate antiviral therapy appears to restrict resting CD4+ cell HIV-1 infection without accelerating the decay of latent infection Activation and lysis of human CD4 cells latently infected with HIV-1 The role of HIV integration in viral persistence: no more whistling past the proviral graveyard.An increasing proportion of monotypic HIV-1 DNA sequences during antiretroviral treatment suggests proliferation of HIV-infected cells Predictors of residual viraemia in patients on long-term suppressive antiretroviral therapy.Persistent HIV-1 replication maintains the tissue reservoir during therapy Modelling HIV-1 2-LTR dynamics following raltegravir intensification.HIV-1 transcription and latency: an update.Lack of concordance between residual viremia and viral variants driving de novo infection of CD4(+) T cells on ART.HIV Maintains an Evolving and Dispersed Population in Multiple Tissues during Suppressive Combined Antiretroviral Therapy in Individuals with Cancer.Residual plasma viraemia and infectious HIV-1 recovery from resting memory CD4 cells in patients on antiretroviral therapy: results from ACTG A5173.Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA.Spatial modeling of HIV cryptic viremia and 2-LTR formation during raltegravir intensification.CD4+ memory stem cells are infected by HIV-1 in a manner regulated in part by SAMHD1 expression.HIV reservoirs and strategies for eradication.Eliminating the HIV reservoir.Developing strategies for HIV-1 eradication Targeting HIV latency: resting memory T cells, hematopoietic progenitor cells and future directions.Potential implication of residual viremia in patients on effective antiretroviral therapy.Towards an HIV-1 cure: measuring the latent reservoir.Eradication of HIV from Tissue Reservoirs: Challenges for the Cure.The Latent Reservoir for HIV-1: How Immunologic Memory and Clonal Expansion Contribute to HIV-1 Persistence.Envelope-specific antibodies and antibody-derived molecules for treating and curing HIV infection HIV antibodies for treatment of HIV infection.Clonal Expansion of Human Immunodeficiency Virus-Infected Cells and Human Immunodeficiency Virus Persistence During Antiretroviral Therapy.

P2860

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P2860

Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cells.

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http://www.wikidata.org/entity/Q35076645

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